年龄对正常受试者茶碱清除率的影响。
The effect of age on theophylline clearance in normal subjects.
作者信息
Randolph W C, Seaman J J, Dickson B, Peace K E, Frank W O, Young M D
出版信息
Br J Clin Pharmacol. 1986 Nov;22(5):603-5. doi: 10.1111/j.1365-2125.1986.tb02941.x.
Abstract
Dose-interval AUC and clearance of theophylline at steady-state were determined in healthy male subjects in each of three age groups (18-35, 36-54 and 55-70 years old). Mean AUC in the oldest group was significantly higher than in the youngest and clearance in both the middle and oldest groups was significantly lower than in the youngest. Though clearance was significantly correlated with age, age alone accounted for only 31% of the variability in clearance.
摘要
在三个年龄组（18 - 35岁、36 - 54岁和55 - 70岁）的健康男性受试者中，测定了稳态下茶碱的剂量间隔曲线下面积（AUC）和清除率。最年长组的平均AUC显著高于最年轻组，而中间组和最年长组的清除率均显著低于最年轻组。虽然清除率与年龄显著相关，但仅年龄一项仅占清除率变异性的31%。
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2
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