同步胰岛素瘤和胰高血糖素瘤：文献复习。
Synchronous Insulinoma and Glucagonoma: A Review of the Literature.
机构信息
Renal Transplantation Unit, Laiko General Hospital, Athens, Greece;
NS Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
In Vivo. 2023 Nov-Dec;37(6):2402-2408. doi: 10.21873/invivo.13345.
BACKGROUND/AIM: Pancreatic neuroendocrine tumors (PNETs) are pancreatic neoplasms with neuroendocrine features, divided into functioning and non-functioning. The non-functioning PNETs are the largest group, and their morbidity is the result of their potential to invade surrounding tissues and metastasize. The functioning PNETs produce hormonal symptoms due to over-secretion of specific hormones. They constitute 1% to 2% of all pancreatic tumors. The use of novel imaging methods has rendered their detection more frequent. Insulinoma, the most common functioning PNET, comprises 35-40% of all functioning PNETs. Its clinical presentation is due to hyperinsulinemia and the subsequent hypoglycemia. Glucagonoma accounts for 5% of all PNETs and is the fourth most frequent functioning PNET, following insulinoma, gastrinoma, and vipoma. Its symptoms are due to the massive secretion of glucagon and ensuing hyperglycemia. The co-existence of two PNETs is a very rare entity. This report aimed to describe cases of concomitant insulinomas and glucagonomas.
MATERIALS AND METHODS
A review of the literature was performed using the PubMed database and Cochrane library aiming to identify reported cases of concomitant pancreatic insulinoma and glucagonoma. Specifically, the research was conducted using the keywords, separately and in various combination, including insulinoma, glucagonoma, cystic, pancreatic neuroendocrine tumors and hypoglycemia. Only publications in English were included in the present study.
RESULTS
A total of 8 cases of concomitant pancreatic insulinoma and glucagonoma were identified, corresponding to the period 1992-2021.
CONCLUSION
Concomitant insulinoma and glucagonoma are rare and challenging. A multidisciplinary approach is necessary for diagnosis, prognosis, and therapy.
背景/目的：胰腺神经内分泌肿瘤（PNETs）是具有神经内分泌特征的胰腺肿瘤，分为功能性和非功能性。非功能性 PNETs 是最大的一组，其发病率是由于其潜在的侵袭周围组织和转移的能力。功能性 PNETs 由于特定激素的过度分泌而产生激素症状。它们构成所有胰腺肿瘤的 1%至 2%。新型成像方法的应用使它们的检测更加频繁。胰岛素瘤是最常见的功能性 PNET，占所有功能性 PNET 的 35-40%。其临床表现是由于高胰岛素血症和随后的低血糖。胰高血糖素瘤占所有 PNET 的 5%，是继胰岛素瘤、胃泌素瘤和 VIP 瘤之后第四常见的功能性 PNET。其症状是由于胰高血糖素的大量分泌和随之而来的高血糖。两个 PNET 同时存在是一种非常罕见的情况。本报告旨在描述同时存在胰岛素瘤和胰高血糖素瘤的病例。
材料和方法
使用 PubMed 数据库和 Cochrane 图书馆对文献进行综述，旨在确定同时存在胰腺胰岛素瘤和胰高血糖素瘤的报告病例。具体来说，使用胰岛素瘤、胰高血糖素瘤、囊性、胰腺神经内分泌肿瘤和低血糖等关键词，分别或组合进行了研究。本研究仅纳入英文出版物。
结果
共发现 8 例同时存在胰腺胰岛素瘤和胰高血糖素瘤的病例，时间范围为 1992 年至 2021 年。
结论
同时存在胰岛素瘤和胰高血糖素瘤是罕见且具有挑战性的。诊断、预后和治疗需要多学科方法。
Zotero 插件