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利用临床适用的3D生物打印构建体增强颅面骨重建

Enhancing Craniofacial Bone Reconstruction with Clinically Applicable 3D Bioprinted Constructs.

作者信息

Lee Hyeongjin, Kengla Carlos, Kim Han Su, Kim Ickhee, Cho Jae-Gu, Renteria Eric, Shin Kyungsup, Atala Anthony, Yoo James J, Lee Sang Jin

机构信息

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

School of Biomedical Engineering and Sciences, Wake Forest University-Virginia Tech, Winston-Salem, NC, 27157, USA.

出版信息

Adv Healthc Mater. 2024 Feb;13(4):e2302508. doi: 10.1002/adhm.202302508. Epub 2023 Nov 12.

DOI:10.1002/adhm.202302508
PMID:37906084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250468/
Abstract

Medical imaging and 3D bioprinting can be used to create patient-specific bone scaffolds with complex shapes and controlled inner architectures. This study investigated the effectiveness of a biomimetic approach to scaffold design by employing geometric control. The biomimetic scaffold with a dense external layer showed improved bone regeneration compared to the control scaffold. New bone filled the defected region in the biomimetic scaffolds, while the control scaffolds only presented new bone at the boundary. Histological examination also shows effective bone regeneration in the biomimetic scaffolds, while fibrotic tissue ingrowth is observed in the control scaffolds. These findings suggest that the biomimetic bone scaffold, designed to minimize competition for fibrotic tissue formation in the bony defect, can enhance bone regeneration. This study underscores the notion that patient-specific anatomy can be accurately translated into a 3D bioprinting strategy through medical imaging, leading to the fabrication of constructs with significant clinical relevance.

摘要

医学成像和3D生物打印可用于制造具有复杂形状和可控内部结构的个性化骨支架。本研究通过采用几何控制来研究仿生方法在支架设计中的有效性。与对照支架相比，具有致密外层的仿生支架显示出更好的骨再生效果。新骨填充了仿生支架中的缺损区域，而对照支架仅在边界处出现新骨。组织学检查还显示仿生支架中有有效的骨再生，而在对照支架中观察到纤维化组织向内生长。这些发现表明，旨在减少骨缺损中纤维化组织形成竞争的仿生骨支架可以增强骨再生。本研究强调了这样一种观念，即通过医学成像可以将患者特定的解剖结构准确地转化为3D生物打印策略，从而制造出具有重要临床意义的构建体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/6236bdbeb3c6/ADHM-13-2302508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/35dc6d4bdd04/ADHM-13-2302508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/7dc473588aa4/ADHM-13-2302508-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/cb57f105cb0f/ADHM-13-2302508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/d02d6022d83a/ADHM-13-2302508-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/a2faa700b462/ADHM-13-2302508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/1378e9d3c89b/ADHM-13-2302508-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/6236bdbeb3c6/ADHM-13-2302508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/35dc6d4bdd04/ADHM-13-2302508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/7dc473588aa4/ADHM-13-2302508-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/cb57f105cb0f/ADHM-13-2302508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/d02d6022d83a/ADHM-13-2302508-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/a2faa700b462/ADHM-13-2302508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/1378e9d3c89b/ADHM-13-2302508-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c64/11468771/6236bdbeb3c6/ADHM-13-2302508-g002.jpg

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