Some B, Cherruault Y
Biomed Pharmacother. 1986;40(5):183-7.
In the literature there does not exist many efficient methods for solving identification and optimal control problems in pharmacokinetics. We present a global optimization method for finding the optimum of functions involving several real variables. This technique can be applied to many identification problems. Furthermore a method of successive derivations for the resolution of optimal control problems associated to compartmental modelling is developed.
文献中不存在许多解决药代动力学中识别和最优控制问题的有效方法。我们提出一种全局优化方法,用于寻找涉及多个实变量的函数的最优值。该技术可应用于许多识别问题。此外,还开发了一种用于解决与房室模型相关的最优控制问题的逐次求导方法。