Wang C Y
Arzneimittelforschung. 1977;27(12):2368-71.
The nonlinear pharmacokinetics applicable to renal excretion is investigated. General solutions are found and simulated concentration-time curves show the effect of various parameters. Equilibrium may or may not exist. An example shows that the additive property of linear pharmacokinetics is no longer valid in the nonlinear case.
研究了适用于肾脏排泄的非线性药代动力学。找到了一般解,模拟的浓度-时间曲线显示了各种参数的影响。平衡可能存在也可能不存在。一个例子表明,线性药代动力学的加和性在非线性情况下不再成立。