视神经脊髓炎谱系疾病中长链非编码 RNA 的显著上调。
Significant up-regulation of lncRNAs in neuromyelitis optica spectrum disorder.
机构信息
Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Sci Rep. 2023 Oct 31;13(1):18692. doi: 10.1038/s41598-023-45457-w.
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating defect. Long non-coding RNAs (lncRNAs) might influence the pathobiology and progression of NMOSD. The current study assessed expression level of NEAT1, PANDAR, MEG3 and TUG1 lncRNAs in the peripheral blood of NMOSD patients compared with healthy individuals. All mentioned lncRNAs were shown to be over-expressed in total NMOSD cases, male NMOSD cases and female NMOSD cases compared with the matching control subgroups. MEG3 had the most robust over-expression in patients subgroups compared with normal subjects. There was no noteworthy difference in the expression of any of lncRNAs between female and male patients. MEG3 had an ideal performance in the differentiation of NMOSD cases from healthy persons (Sensitivity and specificity values = 100%). Other lncRNAs could also efficiently separate NMOSD cases from control subjects (AUC values = 0.97, 0.89 and 0.88 for PANDAR, NEAT1 and TUG1, respectively). Cumulatively, NEAT1, PANDAR, MEG3 and TUG1 lncRNAs can be considered as appropriate disease markers for NMOSD.
视神经脊髓炎谱系疾病（NMOSD）是一种与免疫相关的脱髓鞘疾病。长链非编码 RNA（lncRNA）可能影响 NMOSD 的病理生物学和进展。本研究评估了 NMOSD 患者与健康个体外周血中 NEAT1、PANDAR、MEG3 和 TUG1 lncRNA 的表达水平。与匹配的对照组相比，所有提到的 lncRNA 在总 NMOSD 病例、男性 NMOSD 病例和女性 NMOSD 病例中均呈过度表达。与正常受试者相比，MEG3 在患者亚组中的表达最为显著。lncRNA 在男性和女性患者之间的表达没有显著差异。MEG3 在区分 NMOSD 病例和健康人方面表现出色（敏感性和特异性值=100%）。其他 lncRNA 也能有效地将 NMOSD 病例与对照组区分开来（AUC 值分别为 PANDAR、NEAT1 和 TUG1 的 0.97、0.89 和 0.88）。总之，NEAT1、PANDAR、MEG3 和 TUG1 lncRNA 可作为 NMOSD 的合适疾病标志物。
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