School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
Key Laboratory of Basic and Application Research of Beiyao Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
J Nanobiotechnology. 2023 Oct 31;21(1):400. doi: 10.1186/s12951-023-02158-w.
Cancer has always posed a significant threat to human health, prompting extensive research into new treatment strategies due to the limitations of traditional therapies. Starvation therapy (ST) has garnered considerable attention by targeting the primary energy source, glucose, utilized by cancer cells for proliferation. Glucose oxidase (GOx), a catalyst facilitating glucose consumption, has emerged as a critical therapeutic agent for ST. However, mono ST alone struggles to completely suppress tumor growth, necessitating the development of synergistic therapy approaches. Metal catalysts possess enzyme-like functions and can serve as carriers, capable of combining with GOx to achieve diverse tumor treatments. However, ensuring enzyme activity preservation in normal tissue and activation specifically within tumors presents a crucial challenge. Nanodelivery systems offer the potential to enhance therapy effectiveness by improving the stability of therapeutic agents and enabling controlled release. This review primarily focuses on recent advances in the mechanism of GOx combined with metal catalysts for synergistic tumor therapy. Furthermore, it discusses various nanoparticles (NPs) constructs designed for synergistic therapy in different carrier categories. Finally, this review provides a summary of GOx-metal catalyst-based NPs (G-M) and offers insights into the challenges associated with G-M therapy, delivery design, and oxygen (O) supply.
癌症一直对人类健康构成重大威胁，由于传统疗法的局限性，促使人们广泛研究新的治疗策略。由于靶向癌细胞增殖所利用的主要能源葡萄糖，饥饿疗法 (ST) 引起了相当大的关注。葡萄糖氧化酶 (GOx) 作为促进葡萄糖消耗的催化剂，已成为 ST 的重要治疗剂。然而，单独的单 ST 难以完全抑制肿瘤生长，因此需要开发协同治疗方法。金属催化剂具有酶样功能，可作为载体，与 GOx 结合以实现多种肿瘤治疗。然而，确保正常组织中酶活性的保存以及在肿瘤内的特异性激活是一个关键挑战。纳米递药系统通过提高治疗剂的稳定性和实现控制释放，有潜力提高治疗效果。本综述主要关注 GOx 与金属催化剂联合用于协同肿瘤治疗的最新进展。此外，还讨论了不同载体类别中设计用于协同治疗的各种纳米颗粒 (NP) 构建体。最后，本综述总结了基于 GOx-金属催化剂的 NPs (G-M)，并深入探讨了与 G-M 治疗、输送设计和氧气 (O) 供应相关的挑战。
