Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Department of Ophthalmology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Front Endocrinol (Lausanne). 2023 Jun 1;14:1155296. doi: 10.3389/fendo.2023.1155296. eCollection 2023.
Ferroptosis is iron-dependent regulatory cell death (RCD). Morphologically, ferroptosis is manifested as mitochondrial atrophy and increased mitochondrial membrane density. Biochemically, ferroptosis is characterized by the depletion of glutathione (GSH), the inactivation of glutathione peroxidase 4 (GPX4), and an increase in lipid peroxides (LPO)and divalent iron ions. Ferroptosis is associated with various diseases, but the relationship with diabetic retinopathy(DR) is less studied. DR is one of the complications of diabetes mellitus and has a severe impact on visual function. The pathology of DR is complex, and the current treatment is unsatisfactory. Therefore, exploring pathogenesis is helpful for the clinical treatment of DR. This paper reviews the pathological mechanism of ferroptosis and DR in recent years and the involvement of ferroptosis in the pathology of DR. In addition, we propose problems that need to be addressed in this research field. It is expected to provide new ideas for treating DR by analyzing the role of ferroptosis in DR.
铁死亡是一种铁依赖性的细胞死亡（RCD）。形态学上，铁死亡表现为线粒体萎缩和线粒体膜密度增加。从生物化学角度看，铁死亡的特征是谷胱甘肽（GSH）耗竭、谷胱甘肽过氧化物酶 4（GPX4）失活以及脂质过氧化物（LPO）和二价铁离子增加。铁死亡与多种疾病有关，但与糖尿病性视网膜病变（DR）的关系研究较少。DR 是糖尿病的并发症之一，严重影响视觉功能。DR 的发病机制复杂，目前的治疗效果并不理想。因此，探讨发病机制有助于临床治疗 DR。本文综述了近年来铁死亡和 DR 的病理机制以及铁死亡在 DR 发病机制中的作用，并提出了该研究领域需要解决的问题。通过分析铁死亡在 DR 中的作用，为治疗 DR 提供新的思路。
