Kayabaşı Mustafa, Köksaldı Seher, Mansour Ahmad M, Ayhan Ziya, Saatci Ali Osman
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Department of Ophthalmology, Mus State Hospital, Mus, Turkey.
Clin Ophthalmol. 2023 Oct 25;17:3195-3205. doi: 10.2147/OPTH.S436652. eCollection 2023.
To analyze the multimodal imaging characteristics of intraretinal macroaneurysms.
Intraretinal aneurysms larger than 150 μm in diameter on fluorescein angiography were termed as intraretinal macroaneurysm and grouped as primary and secondary according to the absence or presence of any coexisting posterior segment diseases.
A total of 20 intraretinal macroaneurysms were observed in 18 eyes of 18 patients. Mean age of the cohort was 65.44 ± 9.14 years (Range; 49-82 years). Mean diameters of intraretinal macroaneurysms were 238.20 ± 61.12 μm (Range; 163.00-292.50 μm) and 242.72 ± 49.58 μm (Range; 168.00-328.00 μm) on fluorescein angiography and optical coherence tomography, respectively. Primary group had 10 eyes with 11 intraretinal macroaneurysms, whereas eight eyes had nine intraretinal macroaneurysms in the secondary group. Three of the eight eyes (37.5%) had diabetic retinopathy, four (50%), retinal vein occlusion, and one (12.5%), posterior uveitis in the secondary group. No statistically significant differences were found between the two groups in terms of age, sex, presence of intraretinal or subretinal fluid, the mean age, the mean central macular thickness, the mean distance of intraretinal macroaneurysms from the fovea, the mean diameter of intraretinal macroaneurysms measured on fluorescein angiography, and the mean diameter of intraretinal macroaneurysms measured on optical coherence tomography. Presence of intraretinal fluid was significantly more frequent than the presence of subretinal fluid in all eyes (p = 0.004).
Intraretinal macroaneurysms are diagnosed more and more with the utilization of multimodal imaging techniques. We propose a simple classification system in order to help achieving a standardized terminology and ensure consistent understanding. The classification can be simplified as primary or secondary intraretinal macroaneurysm according to the absence or presence of the associated posterior segment disorders.
分析视网膜内大动脉瘤的多模态成像特征。
荧光素血管造影显示直径大于150μm的视网膜内动脉瘤被称为视网膜内大动脉瘤，并根据是否存在任何并存的后段疾病分为原发性和继发性。
共观察到18例患者18只眼中的20个视网膜内大动脉瘤。该队列的平均年龄为65.44±9.14岁（范围：49 - 82岁）。荧光素血管造影和光学相干断层扫描测量的视网膜内大动脉瘤平均直径分别为238.20±61.12μm（范围：163.00 - 292.50μm）和242.72±49.58μm（范围：168.00 - 328.00μm）。原发性组有10只眼，其中有11个视网膜内大动脉瘤，而继发性组有8只眼，其中有9个视网膜内大动脉瘤。继发性组的8只眼中有3只（37.5%）患有糖尿病性视网膜病变，4只（50%）患有视网膜静脉阻塞，1只（12.5%）患有后葡萄膜炎。两组在年龄、性别、视网膜内或视网膜下液的存在情况、平均年龄、平均中心黄斑厚度、视网膜内大动脉瘤距黄斑中心的平均距离、荧光素血管造影测量的视网膜内大动脉瘤平均直径以及光学相干断层扫描测量的视网膜内大动脉瘤平均直径方面均未发现统计学上的显著差异。所有眼中视网膜内液的存在明显比视网膜下液更常见（p = 0.004）。
随着多模态成像技术的应用，视网膜内大动脉瘤的诊断越来越多。我们提出一个简单的分类系统，以帮助实现标准化术语并确保一致的理解。根据是否存在相关的后段疾病，该分类可简化为原发性或继发性视网膜内大动脉瘤。
