Sagen J, Pappas G D, Perlow M J
Brain Res. 1986 Oct 1;384(1):189-94. doi: 10.1016/0006-8993(86)91238-2.
Adrenal chromaffin cells contain and release several neuroactive substances which induce analgesia when injected directly into the spinal cord (e.g. opioid peptides and catecholamines). Furthermore, the release of these substances can be induced by nicotine. In order to determine whether adrenal medullary tissue transplanted to the spinal cord can produce alterations in pain sensitivity, pieces of dissected rat adrenal medulla were placed in the subarachnoid space of rat spinal cords. Stimulation by a low dose of nicotine induced potent analgesia in animals with adrenal medullary transplants, but not in animals with control transplants. Furthermore, this analgesia was reversed to pre-nicotine levels by the opiate antagonist naloxone. Thus adrenal medullary transplants in the spinal cord may provide a permanent and locally available source of opioid peptides for the relief of intractable pain.
肾上腺嗜铬细胞含有并释放多种神经活性物质，当直接注射到脊髓中时会诱导镇痛作用（例如阿片肽和儿茶酚胺）。此外，尼古丁可诱导这些物质的释放。为了确定移植到脊髓的肾上腺髓质组织是否会引起疼痛敏感性的改变，将 dissected 大鼠肾上腺髓质片置于大鼠脊髓的蛛网膜下腔。低剂量尼古丁刺激在接受肾上腺髓质移植的动物中诱导出强效镇痛作用，但在接受对照移植的动物中则没有。此外，这种镇痛作用被阿片拮抗剂纳洛酮逆转至尼古丁给药前水平。因此，脊髓中的肾上腺髓质移植可能为缓解顽固性疼痛提供一种永久且局部可用的阿片肽来源。
原文中“dissected”可能有误，推测可能是“rat”，翻译时按推测进行了处理，若有误请根据正确内容调整。
