Habel-Verge C, Landry F, Desaulniers D, Dagenais G R, Moisan A, Côté L, Robitaille N M
CMAJ. 1987 Jan 15;136(2):142-7.
To determine whether women with mitral valve prostheses can improve their physical fitness without suffering cardiac dysfunction or hemolysis, 10 women (mean age 47 years) who had undergone mitral valve replacement (an average of 3.7 years earlier) were enrolled in an 8-week program of exercise on a bicycle ergometer. They exercised three times a week, starting at 60% and increasing to 80% of their maximal heart rate achieved during stress testing. Nine other women with similar clinical characteristics (mean age 48 years) constituted a control group. Exercise produced significant cardiovascular improvement, as evidenced by a mean decrease of 12 beats/min in the heart rate at steady-state work load (p less than or equal to 0.01), a mean increase of 121 kpm in the maximal tolerated work load (p less than or equal to 0.01), and a mean increase of 4 ml/kg X min-1 in the peak oxygen consumption (p less than or equal to 0.01). There was a small increase in the mean plasma hemoglobin level (15 to 29 mg/dl) and the mean reticulocyte count (1.8% to 2.4%) after the program (p less than or equal to 0.05). There were no significant changes in any of the variables studied in the control group. There were no changes in the clinical, electrocardiographic or echocardiographic findings in the experimental group. Although slightly increased hemolysis may occur, women with mitral valve replacement can improve their cardiovascular condition by exercising.
为了确定二尖瓣置换术后的女性患者能否在不发生心脏功能障碍或溶血的情况下提高身体素质，我们招募了10名女性（平均年龄47岁），她们均已接受二尖瓣置换术（平均时间为3.7年前），参与一项为期8周的自行车测力计锻炼计划。她们每周锻炼三次，起始强度为应激测试中达到的最大心率的60%，并逐渐增加至80%。另外9名具有相似临床特征的女性（平均年龄48岁）组成了对照组。锻炼使心血管功能得到显著改善，稳态工作负荷下心率平均降低12次/分钟（p≤0.01），最大耐受工作负荷平均增加121千帕米（p≤0.01），峰值耗氧量平均增加4毫升/千克·分钟-1（p≤0.01），这些均证明了这一点。锻炼计划结束后，平均血浆血红蛋白水平略有升高（从15毫克/分升降至29毫克/分升），平均网织红细胞计数也有所增加（从1.8%增至2.4%）（p≤0.05）。对照组所研究的任何变量均无显著变化。实验组的临床、心电图或超声心动图检查结果也无改变。尽管可能会出现轻微的溶血增加，但二尖瓣置换术后的女性患者可以通过锻炼改善心血管状况。
