Xu Ruoxi, Yin Peng, Wei Jifu, Ding Qiang
Department of Pharmacy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China.
Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Front Oncol. 2023 Oct 17;13:1284926. doi: 10.3389/fonc.2023.1284926. eCollection 2023.
The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one of the most important types of mechanical stimulation. Increased matrix stiffness alters the biological activity of cells, which promotes the growth of numerous malignancies, including breast cancer. Comprehensive studies have demonstrated that increasing matrix stiffness activates molecular signaling pathways that are closely linked to breast cancer progression. There are many articles exploring the relationship between mechanism hardness and breast cancer, so we wanted to provide a systematic summary of recent research advances. In this review, we briefly introduce the mechanism of matrix stiffness in breast cancer, elaborate on the effect of extracellular matrix stiffness on breast cancer biological behavior and signaling pathways, and finally, we will talk about breast cancer treatment that focuses on matrix stiffness.
近年来，人们对基质硬度在癌症发展中的意义进行了研究。细胞外基质赋予细胞的逐渐增加的弹力，即基质硬度，是最重要的机械刺激类型之一。基质硬度增加会改变细胞的生物学活性，促进包括乳腺癌在内的多种恶性肿瘤的生长。综合研究表明，增加的基质硬度会激活与乳腺癌进展密切相关的分子信号通路。有许多文章探讨了机制硬度与乳腺癌之间的关系，因此我们想对近期的研究进展进行系统总结。在这篇综述中，我们简要介绍乳腺癌中基质硬度的机制，详细阐述细胞外基质硬度对乳腺癌生物学行为和信号通路的影响，最后，我们将讨论针对基质硬度的乳腺癌治疗。
