Liu Chongshun, Pei Haiping, Tan Fengbo
Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Onco Targets Ther. 2020 Apr 1;13:2747-2755. doi: 10.2147/OTT.S231010. eCollection 2020.
In recent years, a growing consensus is emerging that the mechanical microenvironment of tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis. Matrix stiffness, one of the sources of mechanical stimulation, affects tumor cells as well as non-tumor cells in multiple different molecular signaling pathways in solid tumors such as colorectal tumors, which lead to tumor invasion and metastasis, immune evasion and drug resistance. This review will illustrate the relationship between matrix stiffness and colorectal cancer from the following aspects. First, briefly introduce the mechanical microenvironment and colorectal cancer, then explain the origin of colorectal cancer extracellular matrix stiffness, and then synthesize the study of matrix stiffness of colorectal cancer in recent years to elaborate the effects of extracellular matrix stiffness in colorectal cancer's biological behavior and signaling pathways, and finally we will discuss the transformation treatment for the matrix stiffness of colorectal cancer. An in-depth understanding of matrix stiffness and colorectal cancer can help researchers conduct further experiments to find new targets for the treatment of colorectal cancer.
近年来，越来越多的人达成共识，即肿瘤的机械微环境在肿瘤的发生、进展、侵袭和转移中起着更为关键的作用。基质硬度作为机械刺激的来源之一，在实体瘤（如结直肠癌）的多种不同分子信号通路中影响肿瘤细胞以及非肿瘤细胞，进而导致肿瘤侵袭和转移、免疫逃逸及耐药。本综述将从以下几个方面阐述基质硬度与结直肠癌之间的关系。首先，简要介绍机械微环境和结直肠癌，接着解释结直肠癌细胞外基质硬度的来源，然后综合近年来对结直肠癌基质硬度的研究，阐述细胞外基质硬度对结直肠癌生物学行为和信号通路的影响，最后我们将探讨针对结直肠癌基质硬度的转化治疗。深入了解基质硬度与结直肠癌有助于研究人员开展进一步实验，以寻找治疗结直肠癌的新靶点。
