Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
Scientific and Technological Institute, Brazil University, São Paulo, 08230-030, Brazil.
Curr Pharm Biotechnol. 2024;25(8):1058-1072. doi: 10.2174/0113892010245946230919062908.
Chitosan (CS) is a polycationic polysaccharide comprising glucosamine and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering. Moreover, CS hydrogels are able to promote the expression of cartilage matrix components and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in animal models.
This study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models. The search was done by the descriptors of the Medical Subject Headings (MeSH) defined below: "Chitosan," "hydrogel," "cartilage repair," and "in vivo." A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase, Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different papers from the beginning of 2002 through the middle of 2022.
It was found that cartilage repair was improved with the treatment of CS hydrogel, especially the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes and proteins that act in the cartilage repair process, improving the biomechanical properties of gait..
In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies.
壳聚糖（CS）是一种由氨基葡萄糖和 N-乙酰氨基葡萄糖组成的聚阳离子多糖，是软骨组织工程中潜在的应用材料。此外，CS 水凝胶能够促进软骨基质成分的表达，并减少软骨细胞产生炎症和分解代谢介质。尽管所有这些积极的结果，没有综述分析 CS 水凝胶对动物模型中软骨修复的影响。
本研究旨在通过以下定义的医学主题词（MeSH）描述符检索文献，以检查 CS 水凝胶对实验动物模型中软骨修复的影响：“壳聚糖”、“水凝胶”、“软骨修复”和“体内”。从 Pubmed、Scopus、Embase、Lilacs 和 Web of Science 数据库中检索到 420 篇文章。经过资格分析，本综述报告了 2002 年初至 2022 年年中的 9 篇不同的论文。
发现 CS 水凝胶治疗可改善软骨修复，尤其是富含细胞的 CS 水凝胶。此外，CS 水凝胶产生了在软骨修复过程中起作用的基因和蛋白质的上调，改善了步态的生物力学特性。
总之，CS 水凝胶能够刺激组织向内生长，并加速动物研究中的软骨修复过程。
