Fisher Mandy, Muckle Gina, Lanphear Bruce, Arbuckle Tye E, Braun Joseph M, Zidek Angelika, Vélez Maria P, Lupien Nicole, Bastien Stephanie, Ashley-Martin Jillian, Oulhote Youssef, Borghese Michael M, Walker Mark, Asztalos Elizabeth, Bouchard Maryse F, Booij Linda, Palmert Mark R, Morrison Katherine M, Cummings Elizabeth A, Khatchadourian Karine, Panagiotopoulos Constadina, Glendon Gord, Shutt Robin, Abdul-Fatah Ammanie, Seal Kelsey, Fraser William D
Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Laval Université, Quebec, Quebec, Canada.
Paediatr Perinat Epidemiol. 2023 Nov;37(8):719-732. doi: 10.1111/ppe.13013. Epub 2023 Nov 3.
The pan-Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study was established to determine whether maternal environmental chemical exposures were associated with adverse pregnancy outcomes in 2001 pregnant women.
The MIREC-Child Development (CD PLUS) study followed this cohort with the goal of assessing the potential effects of prenatal exposures on anthropometry and neurodevelopment in early childhood.
MIREC families with children between the ages of 15 months and 5 years who had agreed to be contacted for future research (n = 1459) were invited to participate in MIREC-CD PLUS which combines data collected from an online Maternal Self-Administered Questionnaire with biomonitoring and neurodevelopment data collected from two in-person visits.
Between April 2013 and March 2015, 803 children participated in the Biomonitoring visit where we collected anthropometric measures, blood, and urine from the children. The Behavioural Assessment System for Children-2, Behaviour Rating Inventory of Executive Function, MacArthur-Bates Communicative Development Inventories and the Communication subscale of the Adaptive Behaviour Scale from the Bayley Scales of Infant and Toddler Development-III are available on close to 900 children. There were 610 singleton children who completed in-person visits for neurodevelopment assessments including the Social Responsiveness Scale, Wechsler Preschool Primary Scale of Intelligence-III and NEuroPSYchological assessments (NEPSY). Currently, we are following the cohort into early adolescence to measure the impact of early life exposures on endocrine and metabolic function (MIREC-ENDO).
Data collection for the MIREC-CD PLUS study is complete and analysis of the data continues. We are now extending the follow-up of the cohort into adolescence to measure the impact of early life exposures on endocrine and metabolic function (MIREC-ENDO). MIREC-CD PLUS is limited by loss to follow-up and the fact that mothers are predominately of higher socioeconomic status and 'White' ethnicity, which limits our generalizability. However, the depth of biomonitoring and clinical measures in MIREC provides a platform to examine associations of prenatal, infancy and childhood exposures with child growth and development.
泛加拿大母婴环境化学物质研究（MIREC）于2001年启动，旨在确定孕妇接触环境化学物质是否与不良妊娠结局相关。
MIREC儿童发育（CD PLUS）研究对该队列进行了跟踪，目的是评估产前暴露对幼儿人体测量和神经发育的潜在影响。
邀请了有15个月至5岁孩子且同意为未来研究接受联系的MIREC家庭（n = 1459）参与MIREC-CD PLUS研究，该研究将在线母亲自填问卷收集的数据与两次现场访视收集的生物监测和神经发育数据相结合。
2013年4月至2015年3月期间，803名儿童参与了生物监测访视，我们收集了这些儿童的人体测量数据、血液和尿液。近900名儿童可获得儿童行为评估系统-2、执行功能行为评定量表、麦克阿瑟-贝茨交流发展量表以及贝利婴幼儿发展量表-III适应性行为量表中的交流分量表。有610名单胎儿童完成了包括社会反应量表、韦氏学前儿童智力量表-III和神经心理评估（NEPSY）在内的神经发育评估现场访视。目前，我们正在对该队列进行跟踪直至青春期早期，以测量早期生活暴露对内分泌和代谢功能的影响（MIREC-ENDO）。
MIREC-CD PLUS研究的数据收集工作已完成，数据分析仍在继续。我们现在将该队列的随访扩展至青春期，以测量早期生活暴露对内分泌和代谢功能的影响（MIREC-ENDO）。MIREC-CD PLUS研究受到失访的限制，且母亲大多具有较高的社会经济地位和“白人”种族背景，这限制了研究结果的普遍性。然而，MIREC中生物监测和临床测量的深度为研究产前、婴儿期和儿童期暴露与儿童生长发育之间的关联提供了一个平台。
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