Borghese Michael M, Feng Jingxue, Liang Chun Lei, Kienapple Natasha, Manz Katherine E, Fisher Mandy, Arbuckle Tye E, Atlas Ella, Braun Joseph M, Bouchard Maryse F, Foster Warren, Ashley-Martin Jillian
Environmental Health Science and Research Bureau, Health Canada, 269 Laurier Ave W, Ottawa, ON, Canada.
Health Products and Food Branch, Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON, Canada.
Int J Hyg Environ Health. 2025 Jun;267:114592. doi: 10.1016/j.ijheh.2025.114592. Epub 2025 May 12.
Legacy per- and polyfluoroalkyl substances (PFAS) can promote dyslipidemia; however, evidence is lacking for alternative and precursor PFAS. We investigated associations between serum concentrations of 31 PFAS and concurrently measured lipids and liver function biomarkers.
PFAS, lipids, and liver function biomarkers were analyzed in serum samples provided by 282 adult females participating in a 2018-2021 follow-up study of a Canadian pregnancy cohort. We examined percent differences in outcomes continuously for 17 PFAS with >50% detection and as detected vs. not detected for 14 PFAS with 10-50% detection. We also examined associations with the sum of 7 PFAS recommended by the National Academies of Sciences, Engineering, and Medicine guidance report on PFAS testing and 17 PFAS. We used weighted quantile sum (WQS) and quantile g-computation models to estimate joint associations.
Each two-fold increase in concentrations of PFHxS, PFOS, PFNA, PFDA, PFHpS, and Σ7PFAS were associated with up to 7% higher total and LDL cholesterol and the TC:HDL ratio. Individuals with detectable concentrations of N-EtFOSA, N-MeFOSA, PFBS, and 9Cl-PF3ONS had up to 17% higher total and LDL cholesterol and TC:HDL. Each one-quartile increase in the mixture of 7 PFAS was associated with up to 10% higher total and LDL cholesterol. Adding additional PFAS to the mixture (17 PFAS) made estimates less precise in WQS models and attenuated associations to the null in quantile g-computation models.
Alternative and precursor PFAS, including replacements for legacy PFAS, are associated with higher cholesterol levels; prospective studies are required to confirm these findings.
传统的全氟和多氟烷基物质（PFAS）可导致血脂异常；然而，关于替代型和前体PFAS的证据尚不足。我们研究了31种PFAS的血清浓度与同时检测的血脂和肝功能生物标志物之间的关联。
对参与2018 - 2021年加拿大一个妊娠队列随访研究的282名成年女性提供的血清样本进行PFAS、血脂和肝功能生物标志物分析。我们连续检查了检测率>50%的17种PFAS的结局百分比差异，以及检测率为10 - 50%的14种PFAS的检测与未检测情况。我们还研究了与美国国家科学院、工程院和医学院关于PFAS检测的指导报告推荐的7种PFAS总和以及17种PFAS的关联。我们使用加权分位数和（WQS）和分位数g计算模型来估计联合关联。
全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）、全氟萘酸（PFNA）、全氟癸酸（PFDA）、全氟庚烷磺酸（PFHpS）和7种PFAS总和的浓度每增加两倍，总胆固醇和低密度脂蛋白胆固醇以及总胆固醇与高密度脂蛋白胆固醇比值最多可升高7%。检测到N - 乙基全氟辛烷磺酸（N - EtFOSA）、N - 甲基全氟辛烷磺酸（N - MeFOSA）、全氟丁烷磺酸（PFBS）和9 - 氯全氟丙烷磺酸（9Cl - PF3ONS）的个体，其总胆固醇和低密度脂蛋白胆固醇以及总胆固醇与高密度脂蛋白胆固醇比值最多可升高17%。7种PFAS混合物每增加一个四分位数，总胆固醇和低密度脂蛋白胆固醇最多可升高10%。在WQS模型中，向混合物中添加更多PFAS（17种PFAS）会使估计值不那么精确，而在分位数g计算模型中，关联减弱至无效。
替代型和前体PFAS，包括传统PFAS的替代品，与较高的胆固醇水平相关；需要进行前瞻性研究来证实这些发现。
