Department of Biotechnology, A 10, Jaypee Institute of Information Technology, Sector-62, Noida, Uttar Pradesh, 201309, India.
Clin Exp Med. 2023 Dec;23(8):4065-4077. doi: 10.1007/s10238-023-01234-7. Epub 2023 Nov 3.
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with hyperactive innate and adaptive immune systems that cause dermatological, cardiovascular, renal, and neuropsychiatric problems in patients. SLE's multifactorial nature and complex pathogenesis present significant challenges in its clinical classification. In addition, unpredictable treatment responses in patients emphasize the need for highly specific and sensitive SLE biomarkers that can assist in understanding the exact pathogenesis and, thereby, lead to the identification of novel therapeutic targets. Recent studies on microRNA (miRNA), a non-coding region involved in the regulation of gene expression, indicate its importance in the development of the immune system and thus in the pathogenesis of various autoimmune disorders such as SLE. miRNAs are fascinating biomarker prospects for SLE categorization and disease monitoring owing to their small size and high stability. In this paper, we have discussed the involvement of a wide range of miRNAs in the regulation of SLE inflammation and how their modulation can be a potential therapeutic approach.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，与先天和适应性免疫系统的过度活跃有关，可导致患者出现皮肤科、心血管、肾脏和神经精神问题。SLE 的多因素性质和复杂发病机制使其在临床分类方面存在重大挑战。此外，患者治疗反应的不可预测性强调需要高度特异和敏感的 SLE 生物标志物，以帮助了解确切的发病机制，并由此确定新的治疗靶点。最近关于 microRNA（miRNA）的研究表明，miRNA 在免疫系统的发育中起重要作用，因此在各种自身免疫性疾病（如 SLE）的发病机制中起重要作用。miRNA 作为 SLE 分类和疾病监测的有前途的生物标志物，因其体积小、稳定性高而备受关注。在本文中，我们讨论了广泛的 miRNA 参与 SLE 炎症的调控，以及它们的调节如何成为一种潜在的治疗方法。
