Tsai Chang-Youh, Shen Chieh-Yu, Liu Chih-Wei, Hsieh Song-Chou, Liao Hsien-Tzung, Li Ko-Jen, Lu Cheng-Shiun, Lee Hui-Ting, Lin Cheng-Sung, Wu Cheng-Han, Kuo Yu-Min, Yu Chia-Li
Division of Allergy, Immunology & Rheumatology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 11217, Taiwan.
Division of Rheumatology, Immunology, & Allergy, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Biomolecules. 2020 Dec 6;10(12):1641. doi: 10.3390/biom10121641.
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with heterogeneous clinical manifestations. A diverse innate and adaptive immune dysregulation is involved in the immunopathogenesis of SLE. The dysregulation of immune-related cells may derive from the intricate interactions among genetic, epigenetic, environmental, and immunological factors. Of these contributing factors, non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs), and long non-coding RNAs (lncRNAs) play critical roles in the post-transcriptional mRNA expression of cytokines, chemokines, and growth factors, which are essential for immune modulation. In the present review, we emphasize the roles of ncRNA expression in the immune-related cells and cell-free plasma, urine, and tissues contributing to the immunopathogenesis and tissue damage in SLE. In addition, the circular RNAs (circRNA) and their post-translational regulation of protein synthesis in SLE are also briefly described. We wish these critical reviews would be useful in the search for biomarkers/biosignatures and novel therapeutic strategies for SLE patients in the future.
系统性红斑狼疮（SLE）是一种临床表现多样的复杂系统性自身免疫性疾病。多种先天性和适应性免疫失调参与了SLE的免疫发病机制。免疫相关细胞的失调可能源于遗传、表观遗传、环境和免疫因素之间的复杂相互作用。在这些促成因素中，非编码RNA（ncRNA），包括微小RNA（miRNA，miR）和长链非编码RNA（lncRNA），在细胞因子、趋化因子和生长因子的转录后mRNA表达中起关键作用，而这些因子对于免疫调节至关重要。在本综述中，我们强调ncRNA表达在免疫相关细胞以及无细胞血浆、尿液和组织中的作用，这些因素促成了SLE的免疫发病机制和组织损伤。此外，还简要描述了环状RNA（circRNA）及其在SLE中对蛋白质合成的翻译后调控。我们希望这些重要综述将来在寻找SLE患者的生物标志物/生物特征以及新的治疗策略方面有所帮助。
