Guo Hao, Shen Haifeng, Ma Juping, Wang Penghui, Yao Zheng, Zhang Wenjie, Tan Xiaoyan, Chi Bo
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
China Tobacco Jiangsu Industrial Co., Ltd., Nanjing 210019, P. R. China.
ACS Appl Mater Interfaces. 2023 Nov 3. doi: 10.1021/acsami.3c12027.
Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The hydrogel underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling behavior, degradation kinetics, antibacterial efficacy, hemostatic performance, and biocompatibility. The incorporation of poly(vinyl alcohol) notably enhanced the internal structural stability and injection pressure, while the Laponite content influenced self-healing ability, modulus, and viscosity. Additionally, the hydrogel exhibited pH sensitivity, appropriate degradation, and swelling rates and displayed favorable film-forming and adhesion properties. Notably, it demonstrated excellent resistance against and , highlighting its potential to create an optimal wound environment. studies further confirmed the hydrogel's exceptional hemostatic performance, positioning it as an optimal material for endoscopic submucosal dissection (ESD) surgery. Moreover, cell experiments and hemolysis tests revealed high biocompatibility, supporting their potential to facilitate the healing of iatrogenic ulcers post-ESD surgery. In conclusion, our hydrogels hold great promise as endoscopic treatment materials for ESD-induced ulcers given their outstanding properties.
由于存在出血难以控制的风险，内镜黏膜下剥离手术导致的医源性溃疡仍是一个重大的临床问题。在此，我们开发了一种通过静电相互作用和氢键交联的可注射剪切变稀水凝胶。对该水凝胶进行了全面表征，重点关注流变行为、可注射性、微观结构、成膜能力、粘附性、溶胀行为、降解动力学、抗菌效果、止血性能和生物相容性。聚乙烯醇的加入显著提高了内部结构稳定性和注射压力，而锂皂石含量影响了自愈能力、模量和粘度。此外，该水凝胶表现出pH敏感性、合适的降解和溶胀速率，并具有良好的成膜和粘附性能。值得注意的是，它对[具体细菌1]和[具体细菌2]表现出优异的抗性，突出了其创造最佳伤口环境的潜力。[具体研究]进一步证实了该水凝胶卓越的止血性能，使其成为内镜黏膜下剥离（ESD）手术的理想材料。此外，细胞实验和溶血试验显示出高生物相容性，支持其促进ESD手术后医源性溃疡愈合的潜力。总之，我们的水凝胶因其出色的性能，作为ESD引起的溃疡的内镜治疗材料具有巨大的前景。
