Pimpl W, Thalhamer J, Pattermann M
Eur Surg Res. 1987;19(1):53-61. doi: 10.1159/000128680.
The study deals with the immunological capacity and perfusion rate of splenic grafts in pigs after autologous transplantation into the omentum majus. 12 months after the operation, the weight and relative perfusion of the regenerated tissue was clearly reduced. Independent of this fact, the splenic grafts could balance out an IgM-deficiency, observed due to splenectomy, 4 months after the transplantation. Furthermore, the number of antibody forming cells in the grafts was only slightly decreased compared to the normal spleen. These results show that regenerated splenic tissue is able to carry out specific immunological functions. One of the limiting factors in preventing postsplenectomy sequelae (i.e., sepsis) seems to be the poor regeneration weight and low perfusion of the grafts.
该研究探讨了猪自体移植到大网膜后脾移植的免疫能力和灌注率。术后12个月，再生组织的重量和相对灌注明显降低。尽管如此，脾移植在移植后4个月能够弥补因脾切除导致的IgM缺乏。此外，与正常脾脏相比，移植脾中抗体形成细胞的数量仅略有减少。这些结果表明，再生的脾组织能够执行特定的免疫功能。预防脾切除术后后遗症（即败血症）的限制因素之一似乎是移植脾的再生重量不佳和灌注不足。
