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[脾自体移植的免疫能力与血液循环——猪的实验结果]

[Immunologic capacity and blood circulation of splenic autotransplants--experimental results in swine].

作者信息

Pimpl W, Thalhamer J, Rieger R, Pattermann M

出版信息

Langenbecks Arch Chir. 1986;369:399-403. doi: 10.1007/BF01274398.

DOI:10.1007/BF01274398
PMID:3807553
Abstract

The study deals with the immunological capacity and perfusion rate of splenic grafts in pigs after autologous transplantation into the omentum majus. 12 months after operation the weight and relative blood flow of the regenerated splenic tissue were clearly reduced. The number of antibody forming cells in the grafts was only slightly decreased compared to the normal spleen, whereas the autotransplants could balance a serum-IgM-deficiency, observed due to splenectomy, 4 months after grafting. Furthermore the mitogenic stimulation of T- and B-lymphocytes showed different proliferation rates for the autotransplants compared to the spleen.

摘要

该研究探讨了猪自体脾移植到大网膜后脾移植物的免疫能力和灌注率。术后12个月,再生脾组织的重量和相对血流量明显降低。与正常脾脏相比,移植物中抗体形成细胞的数量仅略有减少,而自体移植在移植后4个月能够平衡因脾切除导致的血清IgM缺乏。此外,与脾脏相比,自体移植的T淋巴细胞和B淋巴细胞的丝裂原刺激显示出不同的增殖率。

相似文献

1
[Immunologic capacity and blood circulation of splenic autotransplants--experimental results in swine].[脾自体移植的免疫能力与血液循环——猪的实验结果]
Langenbecks Arch Chir. 1986;369:399-403. doi: 10.1007/BF01274398.
2
Perfusion of autologous splenic grafts in correlation with specific immunological functions--an experimental study in pigs.自体脾移植灌注与特定免疫功能的相关性——猪的实验研究
Eur Surg Res. 1987;19(1):53-61. doi: 10.1159/000128680.
3
The role of the spleen and splenic autotransplants in clearing experimental bacteremia caused by the gram-negative bacterium Escherichia coli.脾脏及脾自体移植在清除由革兰氏阴性菌大肠杆菌引起的实验性菌血症中的作用。
Res Exp Med (Berl). 1986;186(3):229-38. doi: 10.1007/BF01852049.
4
Alteration of proliferation and subtle changes of protein synthesis in autologous transplanted spleens.自体移植脾脏中增殖的改变及蛋白质合成的细微变化。
Ann Surg. 1989 Nov;210(5):630-6. doi: 10.1097/00000658-198911000-00011.
5
Autotransplantation of splenic tissue.脾组织自体移植。
J Pediatr Surg. 1986 Feb;21(2):120-4. doi: 10.1016/s0022-3468(86)80062-8.
6
Functional value of omental autotransplanted splenic tissue in rabbits.兔自体移植网膜脾组织的功能价值
Isr J Med Sci. 1988 Dec;24(12):706-9.
7
[Experimental study on function of regenerated splenic tissue after splenic autotransplantation].脾自体移植后再生脾组织功能的实验研究
Nihon Geka Gakkai Zasshi. 1990 Nov;91(11):1720-30.
8
[Immunologic function against infection in splenic autotransplanted mice].[脾自体移植小鼠抗感染的免疫功能]
Nihon Geka Gakkai Zasshi. 1991 May;92(5):567-76.
9
The importance of splenic blood flow in clearing pneumococcal organisms.脾血流在清除肺炎球菌中的重要性。
Ann Surg. 1982 Feb;195(2):172-6. doi: 10.1097/00000658-198202000-00009.
10
Immunoarchitecture and specific functions of splenic autotransplants at different implantation sites.
Eur Surg Res. 1992;24(1):22-36. doi: 10.1159/000129185.

本文引用的文献

1
Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
2
[Initial clinical experiences with heterotopic autotransplantation of the spleen].[脾脏异位自体移植的初步临床经验]
Chirurg. 1981 Aug;52(8):525-30.
3
The overwhelming postsplenectomy sepsis problem.脾切除术后严重败血症问题。
World J Surg. 1980 Jul;4(4):423-32. doi: 10.1007/BF02393164.
4
[Transplant conditioning and transplant size in heterotopic autologous spleen transplantation].[异位自体脾移植中的移植预处理与移植大小]
Langenbecks Arch Chir. 1984;362(1):5-16. doi: 10.1007/BF01263315.
5
Splenic regeneration and blood flow after ligation of the splenic artery or partial splenectomy.脾动脉结扎或部分脾切除术后的脾再生与血流
Am J Surg. 1984 Mar;147(3):382-6. doi: 10.1016/0002-9610(84)90172-7.
6
Regeneration and function of autologous splenic grafts in pigs.猪自体脾移植的再生与功能
Eur Surg Res. 1983;15(3):168-75. doi: 10.1159/000128349.
7
Incidental splenectomy: early and late postoperative complications.意外脾切除术:术后早期和晚期并发症
Am J Surg. 1979 Aug;138(2):296-300. doi: 10.1016/0002-9610(79)90390-8.