长期给大鼠施用多巴胺激动剂和拮抗剂药物后，基底神经节中[Met5]-和[Leu5]脑啡肽以及神经降压素含量的变化。

Alterations in [Met5]- and [Leu5]enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats.

作者信息

De Ceballos M L, Boyce S, Jenner P, Marsden C D

出版信息

Eur J Pharmacol. 1986 Nov 4;130(3):305-9. doi: 10.1016/0014-2999(86)90282-7.

Abstract

Treatment of rats for 18 months with trifluoperazine increased [Met5]- and [Leu5]enkephalin and neurotensin content in striatum and nucleus accumbens. However, in substantia nigra the content of [Met5]enkephalin was decreased, [Leu5]enkephalin unchanged and that of neurotensin increased. Administration of L-DOPA plus carbidopa, bromocriptine or pergolide for 12 months decreased [Met5]enkephalin (except bromocriptine) and neurotensin, but not [Leu5]enkephalin, levels in striatum. L-DOPA decreased and bromocriptine increased neurotensin levels in substantia nigra. But neurotensin levels in nucleus accumbens were unaffected.

摘要

用三氟拉嗪对大鼠进行18个月的治疗，可增加纹状体和伏隔核中[Met5]-脑啡肽、[Leu5]-脑啡肽以及神经降压素的含量。然而，黑质中[Met5]-脑啡肽的含量降低，[Leu5]-脑啡肽含量未变，神经降压素含量增加。给予左旋多巴加卡比多巴、溴隐亭或培高利特12个月，可降低纹状体中[Met5]-脑啡肽（溴隐亭除外）和神经降压素的水平，但不影响[Leu5]-脑啡肽的水平。左旋多巴降低了黑质中神经降压素的水平，而溴隐亭则使其升高。但伏隔核中的神经降压素水平未受影响。