Vindrola O, Asai M, Zubieta M, Linares G
Eur J Pharmacol. 1983 May 20;90(1):85-9. doi: 10.1016/0014-2999(83)90216-9.
Wistar rats were injected daily with convulsant doses of PTZ (40 mg/kg). The brain content of immunoreactive (IR) enkephalins was measured after repetitive clonic convulsions and after the 'kindling' state was reached. In both instances we found a significant increase of IR [Leu5]enkephalin and IR [Met5]enkephalin in septum, striatum and amygdala 24 h after PTZ administration. These results support the suggestion that the peptide increase occurs with repetitive convulsions and not only after the 'kindling' state is reached.
每天给Wistar大鼠注射惊厥剂量的戊四氮（PTZ，40毫克/千克）。在反复阵挛性惊厥后以及达到“点燃”状态后，测量脑内免疫反应性（IR）脑啡肽的含量。在这两种情况下，我们发现在给予PTZ后24小时，隔区、纹状体和杏仁核中的IR [亮氨酸5]脑啡肽和IR [甲硫氨酸5]脑啡肽显著增加。这些结果支持这样的观点，即肽的增加是随着反复惊厥而发生的，而不仅仅是在达到“点燃”状态之后。
