Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, 214122, Jiangsu Province, China; Wuxi Medical College, Jiangnan University, Wuxi, 214122, China.
Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Medical College, Inner Mongolia Minzu University, Tongliao, 028000, China.
Int J Biol Macromol. 2024 Jan;254(Pt 2):127789. doi: 10.1016/j.ijbiomac.2023.127789. Epub 2023 Nov 4.
The quick progress of epigenetic study has kindled new hope for treating many cancers. When it comes to RNA epigenetics, the ac4C acetylation modification is showing promise, whereas N-acetyltransferase 10 plays a wide range of biological functions, has a significant impact on cellular life events, and is frequently highly expressed in many malignant tumors. N-acetyltransferase 10 is an acetyltransferase with important biological involvement in cellular processes and lifespan. Because it is highly expressed in many malignant tumors, it is considered a pro-carcinogenic gene. The review aims to introduce NAT10, summarize the effects of ac4C acetylation on tumor growth from multiple angles, and discuss the possible therapeutic targeting of NAT10 and the future directions of ac4C acetylation investigations.
表观遗传学研究的快速进展为治疗许多癌症燃起了新的希望。在 RNA 表观遗传学中，ac4C 乙酰化修饰显示出了前景，而 N-乙酰基转移酶 10 则发挥着广泛的生物学功能，对细胞生命事件有着重大影响，并且在许多恶性肿瘤中常常高度表达。N-乙酰基转移酶 10 是一种乙酰转移酶，在细胞过程和寿命中有重要的生物学参与。由于它在许多恶性肿瘤中高度表达，因此被认为是一种致癌基因。本综述旨在介绍 NAT10，从多个角度总结 ac4C 乙酰化对肿瘤生长的影响，并讨论 NAT10 的可能治疗靶点和 ac4C 乙酰化研究的未来方向。
