• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

应用牛骨移植复合物于拔牙窝后，核因子-κB 受体激活剂配体和骨保护素的表达和比值。

Expression and ratio of receptor activator of nuclear factor kappa-B ligand and osteoprotegerin following application of /bovine bone graft combination in post tooth extraction sockets.

机构信息

Department of Prosthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

出版信息

J Indian Prosthodont Soc. 2023 Jul-Sep;23(3):277-284. doi: 10.4103/jips.jips_198_23.

DOI:10.4103/jips.jips_198_23
PMID:37929367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10467318/
Abstract

AIMS

The aim of this study was to analyze the induction effect of a combination of N. sativa and bovine bone graft on the expression and ratio of receptor activator of nuclear factor kappa-B ligand expression (RANKL) and osteoprotegerin (OPG) on alveolar bone socket preservation on days 7 and 14.

SETTINGS AND DESIGN

The research incorporated a posttest-only control group design. A total of 56 Cavia cobaya were divided into four groups: a control group, an N. sativa group, a bovine bone graft group, and a combined N. sativa and bovine bone graft group.

MATERIALS AND METHODS

The lower incisors of the C. cobaya were extracted with material subsequently being applied to the resulting socket. After the 7 and 14 days, the experimental animals were terminated to enable observation of the socket. Following processing, the tissue was subjected to immunohistochemistry staining consisting of RANKL and OPG antibodies before being observed under a light microscope at × 400.

STATISTICAL ANALYSIS USED

Statistical analysis was carried out using the one-way ANOVA and Tukey's honestly significant difference tests.

RESULTS

A combination of N. sativa and bovine bone graft reduced both RANKL expression and the RANKL/OPG ratio while increasing OPG expression in comparison to the other groups. In all the results obtained, the N. sativa and bovine bone graft combination was significant (P < 0.05) when compared to the control group on both the 7 and 14 days.

CONCLUSION

A combination of N. sativa and bovine bone graft reduced both RANKL expression and the RANKL/OPG ratio while increasing OPG expression.

摘要

目的

本研究旨在分析孜然和牛骨移植物联合应用对第 7 天和第 14 天牙槽骨窝保存中核因子κB 受体激活剂配体表达（RANKL）和骨保护素（OPG）表达和比例的诱导作用。

设置和设计

本研究采用了后测试仅对照组设计。共有 56 只豚鼠被分为四组：对照组、孜然组、牛骨移植物组和孜然和牛骨移植物联合组。

材料和方法

用材料提取豚鼠的下切牙，随后将材料应用于形成的牙槽窝。在第 7 天和第 14 天，处死实验动物以观察牙槽窝。处理后，用 RANKL 和 OPG 抗体进行免疫组织化学染色，然后在 ×400 光镜下观察。

统计学分析方法

采用单因素方差分析和 Tukey Honestly Significant Difference 检验进行统计学分析。

结果

与其他组相比，孜然和牛骨移植物联合应用降低了 RANKL 表达和 RANKL/OPG 比值，同时增加了 OPG 表达。在所有获得的结果中，与对照组相比，孜然和牛骨移植物联合组在第 7 天和第 14 天均有显著差异（P<0.05）。

结论

孜然和牛骨移植物联合应用降低了 RANKL 表达和 RANKL/OPG 比值，同时增加了 OPG 表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/e27ce10a75bb/JIPS-23-277-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/b800853ca93d/JIPS-23-277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/08dca1ac0fee/JIPS-23-277-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/9e3471d900f4/JIPS-23-277-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/3653d474e86f/JIPS-23-277-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/25ce35b8b78c/JIPS-23-277-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/41fc725caddd/JIPS-23-277-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/e27ce10a75bb/JIPS-23-277-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/b800853ca93d/JIPS-23-277-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/08dca1ac0fee/JIPS-23-277-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/9e3471d900f4/JIPS-23-277-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/3653d474e86f/JIPS-23-277-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/25ce35b8b78c/JIPS-23-277-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/41fc725caddd/JIPS-23-277-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10467318/e27ce10a75bb/JIPS-23-277-g007.jpg

相似文献

1
Expression and ratio of receptor activator of nuclear factor kappa-B ligand and osteoprotegerin following application of /bovine bone graft combination in post tooth extraction sockets.应用牛骨移植复合物于拔牙窝后，核因子-κB 受体激活剂配体和骨保护素的表达和比值。
J Indian Prosthodont Soc. 2023 Jul-Sep;23(3):277-284. doi: 10.4103/jips.jips_198_23.
2
Socket preservation using a combination of propolis extract and bovine bone graft towards the expression of receptor activator of nuclear κB ligand and osteoprogerin.采用蜂胶提取物和牛骨移植物保存牙槽窝以表达核因子-κB 受体激活剂和骨保护素。
Folia Med (Plovdiv). 2023 Oct 31;65(5):737-743. doi: 10.3897/folmed.65.e95802.
3
Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts.核因子κB受体激活剂、核因子κB受体激活剂配体及骨保护素在根尖周囊肿中的表达与分布
J Endod. 2015 Aug;41(8):1281-7. doi: 10.1016/j.joen.2015.03.025. Epub 2015 May 5.
4
Expression of receptor activator of nuclear factor -kappaB ligand, receptor activator of nuclear factor -kappaB, and osteoprotegerin, following low-level laser treatment on deproteinized bovine bone graft in rats.低强度激光照射大鼠脱蛋白牛骨移植材料后核因子κB受体活化因子配体、核因子κB受体活化因子及骨保护素的表达
Lasers Med Sci. 2009 Jul;24(4):577-84. doi: 10.1007/s10103-008-0614-7. Epub 2008 Sep 30.
5
RNA isolation from alveolar bone and gene expression analysis of RANK, RANKL and OPG: A new tool to monitor bone remodeling and healing in different bone substitutes used for prosthetic rehabilitation.从肺泡骨中提取 RNA 并分析 RANK、RANKL 和 OPG 的基因表达：一种用于监测不同用于修复体的骨替代物中的骨重建和愈合的新工具。
Arch Oral Biol. 2017 Aug;80:56-61. doi: 10.1016/j.archoralbio.2017.03.011. Epub 2017 Mar 28.
6
Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats.氨氯地平和阿托伐他汀通过调节自发性高血压大鼠中核因子κB配体受体激活剂/核因子κB受体激活剂/骨保护素系统改善高血压性心肌肥厚。
Exp Biol Med (Maywood). 2016 Jun;241(11):1237-49. doi: 10.1177/1535370216630180. Epub 2016 Feb 22.
7
[Osteoprotegerin mRNA/receptor activator of NF-kappaB ligand mRNA expressions in bone tissues of glucocorticoid-induced osteonecrosis of the femoral head].[糖皮质激素性股骨头坏死骨组织中骨保护素mRNA/核因子κB受体活化因子配体mRNA表达]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Oct;22(10):1161-4.
8
Effect of Wenhua Juanbi Recipe () on expression of receptor activator of nuclear factor kappa B ligand, osteoprotegerin, and tumor necrosis factor receptor superfamily member 14 in rats with collagen-induced arthritis.文化蠲痹方对胶原诱导性关节炎大鼠核因子κB受体活化因子配体、骨保护素及肿瘤坏死因子受体超家族成员14表达的影响
Chin J Integr Med. 2017 Mar;23(3):208-214. doi: 10.1007/s11655-016-2532-z. Epub 2016 Dec 21.
9
Osteoprotegerin/Receptor Activator of Nuclear Factor-Kappa B Ligand/Receptor Activator of Nuclear Factor-Kappa B Axis in Obesity, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver Disease.肥胖、2 型糖尿病和非酒精性脂肪性肝病中的护骨素/核因子-κB 配体/核因子-κB 受体激活剂轴。
Curr Obes Rep. 2023 Jun;12(2):147-162. doi: 10.1007/s13679-023-00505-4. Epub 2023 May 19.
10
Evaluation of two formulations containing mineral trioxide aggregate on delayed tooth replantation: relevance of RANKL/RANK/OPG system.含矿物三氧化物凝聚体的两种制剂对延迟牙再植的评估：RANKL/RANK/OPG系统的相关性
Odontology. 2016 May;104(2):211-9. doi: 10.1007/s10266-015-0204-7. Epub 2015 Apr 21.

本文引用的文献

1
The effect of local application of thymoquinone, 's bioactive component, on bone healing in experimental bone defects infected with .百里醌的生物活性成分局部应用对感染……的实验性骨缺损中骨愈合的影响。 你提供的原文似乎不完整，“infected with”后面缺少具体感染物的信息 。
J Periodontal Implant Sci. 2022 Jun;52(3):206-219. doi: 10.5051/jpis.2101360068.
2
Multiple roles of Runt-related transcription factor-2 in tooth eruption: bone formation and resorption.Runt 相关转录因子-2 在牙齿萌出中的多重作用：骨形成和吸收。
Arch Oral Biol. 2022 Sep;141:105484. doi: 10.1016/j.archoralbio.2022.105484. Epub 2022 Jun 15.
3
Thymoquinone loading into hydroxyapatite/alginate scaffolds accelerated the osteogenic differentiation of the mesenchymal stem cells.
姜黄素载入羟基磷灰石/海藻酸钠支架可加速间充质干细胞的成骨分化。
Biomed Eng Online. 2021 Aug 4;20(1):76. doi: 10.1186/s12938-021-00916-1.
4
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption.骨细胞相关细胞因子调节破骨细胞的形成和骨吸收。
Int J Mol Sci. 2020 Jul 21;21(14):5169. doi: 10.3390/ijms21145169.
5
RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling.RANKL/RANK/OPG 通路：运动诱导骨重塑的机制。
Biomed Res Int. 2020 Feb 19;2020:6910312. doi: 10.1155/2020/6910312. eCollection 2020.
6
Comparative Immunomodulatory Activity of L. Preparations on Proinflammatory Mediators: A Focus on Asthma.乳酸菌制剂对促炎介质的比较免疫调节活性：聚焦于哮喘
Front Pharmacol. 2018 Oct 2;9:1075. doi: 10.3389/fphar.2018.01075. eCollection 2018.
7
Lenalidomide regulates osteocytes fate and related osteoclastogenesis via IL-1β/NF-κB/RANKL signaling.来那度胺通过 IL-1β/NF-κB/RANKL 信号通路调节破骨细胞前体细胞向成骨细胞分化及其相关的破骨细胞生成。
Biochem Biophys Res Commun. 2018 Jun 22;501(2):547-555. doi: 10.1016/j.bbrc.2018.05.035. Epub 2018 May 10.
8
TNF‑α and RANKL promote osteoclastogenesis by upregulating RANK via the NF‑κB pathway.TNF-α 和 RANKL 通过 NF-κB 通路上调 RANK 促进破骨细胞生成。
Mol Med Rep. 2018 May;17(5):6605-6611. doi: 10.3892/mmr.2018.8698. Epub 2018 Mar 7.
9
Icariin Enhances Bone Repair in Rabbits with Bone Infection during Post-infection Treatment and Prevents Inhibition of Osteoblasts by Vancomycin.淫羊藿苷在感染后治疗期间增强兔骨感染的骨修复，并防止万古霉素对成骨细胞的抑制。
Front Pharmacol. 2017 Oct 31;8:784. doi: 10.3389/fphar.2017.00784. eCollection 2017.
10
Comparative Effectiveness of Bone Grafting Using Xenograft Freeze-Dried Cortical Bovine, Allograft Freeze-Dried Cortical New Zealand White Rabbit, Xenograft Hydroxyapatite Bovine, and Xenograft Demineralized Bone Matrix Bovine in Bone Defect of Femoral Diaphysis of White Rabbit: Experimental Study In Vivo.异种冻干皮质牛骨、同种冻干皮质新西兰白兔骨、异种羟基磷灰石牛骨和异种脱矿骨基质牛骨用于白兔股骨干骨缺损骨移植的比较效果：体内实验研究
Int J Biomater. 2017;2017:7571523. doi: 10.1155/2017/7571523. Epub 2017 Sep 28.