Department of periodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China.
Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA; Shanghai Stomatological Hospital, Fudan University, No. 356, Beijing Road East, Shanghai, China.
Arch Oral Biol. 2022 Sep;141:105484. doi: 10.1016/j.archoralbio.2022.105484. Epub 2022 Jun 15.
The aim was to provide a comprehensive review of the current knowledge of the multiple roles of Runt-related transcription factor-2 (RUNX2) in regulating tooth eruption, focusing on the molecular mechanisms regarding tooth eruption mediated by RUNX2.
Relevant literatures in PubMed, Medline, and Scopus database were searched, and a narrative review was performed. The multiple roles of RUNX2 in regulating tooth eruption was reviewed and discussed.
Aberrant RUNX2 expression leads to disturbed or failed tooth eruption. Tooth eruption involves both the process of bone formation and bone resorption. RUNX2 promotes osteogenesis around the radicular portion of the dental follicle that provides the biological force for tooth eruption through inducing the expression of osteogenesis-related genes in dental follicle cells/osteoblasts. On the other hand, through indirect and direct pathways, RUNX2 regulates osteoclastogenesis and the formation of the eruption pathway.
RUNX2 exerts a pivotal and complex influence in regulating tooth eruption. This review provides a better understanding of the function of RUNX2 in tooth eruption, which is beneficial to illuminate the precise molecular mechanism of osteogenesis and bone resorption, aiding the development of effective therapy for the failure of tooth eruption.
本文旨在全面综述 runt 相关转录因子 2（RUNX2）在调控牙齿萌出中的多重作用，重点探讨 RUNX2 介导的牙齿萌出的分子机制。
在 PubMed、Medline 和 Scopus 数据库中检索相关文献，并进行叙述性综述。综述和讨论了 RUNX2 在调控牙齿萌出中的多重作用。
异常的 RUNX2 表达导致牙齿萌出异常或失败。牙齿萌出涉及骨形成和骨吸收两个过程。RUNX2 通过诱导牙周膜细胞/成骨细胞中骨发生相关基因的表达，促进根尖部牙周膜的成骨，为牙齿萌出提供生物学力。另一方面，RUNX2 通过间接和直接途径调节破骨细胞生成和萌出途径的形成。
RUNX2 在调控牙齿萌出中发挥着关键而复杂的作用。本综述加深了对 RUNX2 在牙齿萌出中作用的理解，有助于阐明成骨和骨吸收的精确分子机制，为牙齿萌出失败的有效治疗提供帮助。
