Laboratory of Optics and Vision (LOV), School of Medicine, University of Crete, Greece; Ophthalmology Department, University Hospital of Heraklion, Crete, Greece.
Laboratory of Optics and Vision (LOV), School of Medicine, University of Crete, Greece.
J Optom. 2024 Apr-Jun;17(2):100502. doi: 10.1016/j.optom.2023.100502. Epub 2023 Nov 4.
Silicone oil is used as endotamponade following vitreoretinal surgery to maintain the retina reattached when indicated. This study investigates the hypothesis that silicone oil causes insulation effects on the retina by affecting its response to light.
Electrophysiological responses to a flash stimulus were recorded using full-field electroretinography (ERG) and visual evoked potentials (VEP). Recordings were performed in 9 patients who underwent surgery for retinal detachment, before (1-2 days) and after (2-3 weeks) silicone oil removal (SOR) in both the study and the control eye. Flash ERG and VEP recordings were performed according to the ISCEV standard protocol.
Statistically significant differences were found in the study eye in the amplitudes of the ERG responses and their corresponding ratios, i.e. the amplitude after SOR over the amplitude before SOR, in all conditions tested. No differences were observed in the control eye. The mean ratio of photopic ERG response was 3.4 ± 2.4 for the study and 1.0 ± 0.3 for the control eye (p<0.001). The mean ratio of ERG flicker response was 3.1 ± 2.4 and 1.0 ± 0.3, respectively (p = 0.003). Scotopic flash ERG ratio was 5.0 ± 4.4 for the study and 1.3 ± 0.6 for the control eye (p = 0.012). No differences were observed for the amplitude and latency of flash VEP response after SOR.
Silicone oil causes a reduction in flash ERG responses; no effect was found on flash VEP responses. ERGs in eyes filled with silicone oil should not be considered representative of retinal functionality, in contrast to VEPs, which are not affected by silicone oil presence.
硅油被用作玻璃体视网膜手术后的眼内填塞物，以维持视网膜在需要时的附着。本研究假设硅油通过影响视网膜对光的反应而对其产生绝缘作用。
使用全视野视网膜电图（ERG）和视觉诱发电位（VEP）记录闪光刺激的电生理反应。对 9 名接受视网膜脱离手术的患者进行了研究，在硅油取出术（SOR）前（1-2 天）和后（2-3 周）分别对研究眼和对照眼进行了记录。闪光 ERG 和 VEP 记录按照 ISCEV 标准方案进行。
在研究眼中，所有测试条件下，ERG 反应幅度及其相应比值（即 SOR 后与 SOR 前的比值）均存在统计学显著差异。在对照眼中未观察到差异。光 ERG 反应的平均比值为研究眼 3.4 ± 2.4，对照眼 1.0 ± 0.3（p<0.001）。ERG 闪烁反应的平均比值分别为 3.1 ± 2.4 和 1.0 ± 0.3（p = 0.003）。研究眼的暗闪光 ERG 比值为 5.0 ± 4.4，对照眼为 1.3 ± 0.6（p = 0.012）。SOR 后闪光 VEP 反应的振幅和潜伏期无差异。
硅油会导致闪光 ERG 反应减弱；但对闪光 VEP 反应没有影响。填充硅油的眼睛的 ERG 不应被视为视网膜功能的代表性指标，而 VEP 则不受硅油存在的影响。
