内质网-线粒体接触位点在线粒体 DNA 动力学、维持和分布中的作用。

ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution.

机构信息

Groupe de Recherche en Signalisation Cellulaire and Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada; Centre d'Excellence en Recherche sur les Maladies Orphelines - Fondation Courtois, Université du Québec à Montréal, Montréal, Québec, Canada; Réseau Intersectoriel de Recherche en Santé de l'Université du Québec (RISUQ), Canada.

出版信息

Int J Biochem Cell Biol. 2024 Jan;166:106492. doi: 10.1016/j.biocel.2023.106492. Epub 2023 Nov 4.

DOI:10.1016/j.biocel.2023.106492

PMID:37931682

Abstract

Mitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the mitochondrial network and interact with each other. mtDNA replication and nucleoid distribution is an active process regulated by the complex interplay of mitochondrial dynamics, endoplasmic reticulum (ER)-mitochondria contact sites, and cytoskeletal networks. For example, defects in mitochondrial fusion and fission or ER-mitochondria contact sites affect nucleoid maintenance and distribution. In this review, we discuss the process of nucleoid dynamics and the factors regulating nucleoid maintenance and distribution.

摘要

线粒体是细胞代谢的中心枢纽。它们的功能需要核 DNA 编码的蛋白质，但也需要线粒体 DNA（mtDNA），mtDNA 的维持对于细胞器的正常功能至关重要。mtDNA 维持和分布的缺陷与线粒体疾病有关。mtDNA 组织成称为核小体的核蛋白复合物，这些核小体沿着线粒体网络动态移动并相互作用。mtDNA 复制和核小体分布是一个由线粒体动力学、内质网（ER）-线粒体接触位点和细胞骨架网络之间复杂相互作用调节的活跃过程。例如，线粒体融合和分裂或 ER-线粒体接触位点的缺陷会影响核小体的维持和分布。在这篇综述中，我们讨论了核小体动力学的过程以及调节核小体维持和分布的因素。