磺酸功能化金属有机框架的制备及其在预煮食品中对羟基苯甲酸酯和磺胺类药物的在线固相萃取中的应用。

Preparation of sulfonic acid functionalized metal organic frameworks and their application in the online solid phase extraction of parabens and sulfonamides in pre-cooked foods.

作者信息

Fang Min, Ke Jianyang, Wang Zhaojie, Fu Qing, Yang Qing, Xu Lin, Lu Yuepeng, Yang Yong, Jiang Xiaoming, Wu Yongning, Gong Zhiyong, Liu Xin

机构信息

Key Laboratory of Edible Oil Quality and Safety, State Administration for Market Regulation, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, College of Food Science and Engineering, Wuhan Polytechnic University, 68Xuefu South Road, Changqing Garden, Wuhan 430023, China.

Wuhan Institute for Food and Cosmetic Control, 1137 Jinshan Avenue, Wuhan 430012, China.

出版信息

Food Chem X. 2024 Dec 9;25:102074. doi: 10.1016/j.fochx.2024.102074. eCollection 2025 Jan.

UNLABELLED

Mixed-mode sorbents exhibit two or more primary retention mechanisms, which can enhance the selectivity and capacity of the extraction process in a single step. In this study, a facile approach was proposed to prepare functionalized metal-organic frameworks (MOFs) by post-synthetic oxidation. The composites could be varied independently for each processing step, resulting in four frameworks to meet different sample pretreatment requirements. Then, the fabricated MOFs were used as sorbents for the extraction and enrichment acidic and neutral compounds on an online solid phase extraction. The sorbents exhibited a dual retention mechanism combining hydrophilic-lipophilic balance and cation exchange interactions. Excellent linearity was observed over a range of 0.5-5000 μg kg-1 for the parabens and 10-50,000 μg kg-1 for the sulfonamides in pre-cooked foods. The detection limits were 0.02 and 1.27 μg kg-1, respectively. This method provided a novel mixed-mode framework for simultaneous determination of acidic and neutral compounds in complex samples.

KEYWORDS

Sulfonic acid functionalized metal-organic frameworksParabensSulfonamidesOnline solid phase extractionPre-cooked foods.

未标记

混合模式吸附剂具有两种或更多种主要保留机制，可在单个步骤中提高萃取过程的选择性和容量。在本研究中，提出了一种通过合成后氧化制备功能化金属有机框架（MOF）的简便方法。每个处理步骤的复合材料可以独立变化，从而产生四种框架以满足不同的样品预处理要求。然后，将制备的MOF用作在线固相萃取中萃取和富集酸性和中性化合物的吸附剂。吸附剂表现出亲脂平衡和阳离子交换相互作用相结合的双重保留机制。对于预煮食品中的对羟基苯甲酸酯，在0.5 - 5000μg kg-1范围内观察到出色的线性，对于磺胺类药物，在10 - 50,000μg kg-1范围内观察到出色的线性。检测限分别为0.02和1.27μg kg-1。该方法为同时测定复杂样品中的酸性和中性化合物提供了一种新型混合模式框架。