Chemical composition of essential oil from Kosterm and its effect on the susceptibility and biofilm activities of and .

The chemical composition of the essential oil of (Lauraceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The antifungal activity of essential oil was tested against and using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. A total of 28 components (99.6%) were successfully identified, which were characterised by β-eudesmol (14.6%), -α-bergamotene (11.0%), α-copaene (8.5%), dodecen-1-ol (8.5%), and ()-nerolidol (8.3%). The essential oil exhibited activity against and with MIC values of 250 and 500 µg/mL, respectively. The essential oil increased the biofilm of by 38.25%, however, decreased the biofilm of by 47.89% when treated with 500 µg/mL. Thus, the essential oil has a promising application in dentistry inhibition of the growth of and However, the antibiofilm activity of the essential oil is only applicable for cariogenic