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多囊卵巢综合征:现状与未来展望。

Polycystic ovary syndrome: Current scenario and future insights.

机构信息

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India.

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India; Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh 462030, India.

出版信息

Drug Discov Today. 2023 Dec;28(12):103821. doi: 10.1016/j.drudis.2023.103821. Epub 2023 Nov 5.

Abstract

Polycystic ovary syndrome (PCOS) prevails in approximately 33% of females of reproductive age globally. Although the root cause of the disease is unknown, attempts are made to clinically manage the disturbed hormone levels and symptoms arising due to hyperandrogenism, a hallmark of PCOS. This review presents detailed insights on the etiology, risk factors, current treatment strategies, and challenges therein. Medicinal agents currently in clinical trials and those in the development pipeline are emphasized. The significance of the inclusion of herbal supplements in PCOS and the benefits of improved lifestyle are also explained. Last, emerging therapeutic targets for treating PCOS are elaborated. The present review will assist the research fraternity working in the concerned domain to access significant knowledge associated with PCOS.

摘要

多囊卵巢综合征(PCOS)在全球约 33%的育龄女性中流行。尽管该病的根本原因尚不清楚,但人们尝试对因高雄激素血症引起的激素水平紊乱和症状进行临床管理,高雄激素血症是 PCOS 的一个标志。本文综述了该病的病因、危险因素、现有治疗策略及其面临的挑战。重点介绍了目前处于临床试验和开发阶段的药物。还解释了将草药补充剂纳入 PCOS 以及改善生活方式的益处的重要性。最后,阐述了治疗 PCOS 的新兴治疗靶点。本文综述将帮助从事相关领域研究的同仁了解与 PCOS 相关的重要知识。

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