Giles G M, Brady L W
Int J Radiat Oncol Biol Phys. 1986 Dec;12(12):2117-25. doi: 10.1016/0360-3016(86)90010-6.
The interim results of planned lymphadenectomy and 125Iodine implantation for carcinoma of the prostate in 122 patients are reported. The incidence of positive pelvic lymph nodes found at lymphadenectomy ranged from 15% in A-2 to 55% in B-2 lesions, as well as in 13% of well-differentiated tumors. Poorly differentiated histology, B-2 and D-1 tumors, had early treatment failure indicating a group of patients in whom this procedure is contraindicated. Occult disease (A-2) and well-differentiated tumors do not exhibit early failure. However, these patients will also fare well with radical external radiation or prostatectomy. The radiobiology of the low dose rate continuous irradiation of 125Iodine is questioned. It may be inadequate for long-term tumor control. Longer follow-up of this series may indicate that external radiation for clinically localized carcinoma of the prostate is the most effective treatment policy.
报告了122例前列腺癌患者计划进行淋巴结清扫术和碘-125植入的中期结果。淋巴结清扫术中发现盆腔淋巴结阳性的发生率在A-2期病变中为15%，在B-2期病变中为55%，在13%的高分化肿瘤中也有发现。低分化组织学、B-2和D-1期肿瘤出现早期治疗失败，表明这部分患者禁忌进行该手术。隐匿性疾病（A-2期）和高分化肿瘤未出现早期失败。然而，这些患者接受根治性外照射或前列腺切除术也会有良好预后。碘-125低剂量率持续照射的放射生物学存在疑问。它可能不足以实现长期肿瘤控制。对该系列进行更长时间的随访可能表明，对于临床局限性前列腺癌，外照射是最有效的治疗策略。
