el-Mahdi A M, Kuban D A, Schellhammer P F
Am J Clin Oncol. 1985 Dec;8(6):477-80. doi: 10.1097/00000421-198512000-00006.
Of 286 evaluable patients definitively irradiated for adenocarcinoma of the prostate, 71 with Stage B2 and C poorly differentiated lesions were studied. Forty-six patients were treated with external beam therapy and 25 with 125I implantation and pelvic lymph node dissection. Within both the external beam and the 125I treatment groups, the local recurrence rate was noticeably higher in the Stage C than in the Stage B2 tumors. Moreover, the incidence of local failure was significantly increased in those patients treated with 125I implantation, 56% vs. 24% (p = 0.008), suggesting that external beam irradiation may be the treatment of choice for localized, poorly differentiated prostatic tumors.
在286例接受前列腺腺癌根治性放疗的可评估患者中，对71例B2期和C期低分化病变患者进行了研究。46例患者接受了外照射治疗，25例接受了¹²⁵I植入联合盆腔淋巴结清扫术。在外照射组和¹²⁵I治疗组中，C期肿瘤的局部复发率明显高于B2期肿瘤。此外，¹²⁵I植入治疗患者的局部失败发生率显著增加，分别为56%和24%（p = 0.008），这表明外照射可能是局限性、低分化前列腺肿瘤的首选治疗方法。
