Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Pharmaceutical Microbiology Group, Pharmaceutical Quality Assurance Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Arch Microbiol. 2023 Nov 8;205(12):375. doi: 10.1007/s00203-023-03713-7.
Microbial proteases are enzymes secreted by a variety of microorganisms, including bacteria and fungi, and have attracted significant attention due to their versatile applications in the food and pharmaceutical industries. In addition, certain proteases have been used in the development of skin health products and cosmetics. This article provides a review of microbial proteases in terms of their classification, sources, properties, and applications. Moreover, different pharmacological and molecular investigations have been reviewed. Various biological activities of microbial proteases, such as Arazyme, collagenase, elastin, and Nattokinase, which are involved in the digestion of dietary proteins, as well as their potential anti-inflammatory, anti-cancer, antithrombotic, and immunomodulatory effects have been included. Furthermore, their ability to control infections and treat various disorders has been discussed. Finally, this review highlights the potential applications and future perspectives of microbial proteases in biotechnology and biomedicine, and proposes further studies to develop new perspectives for disease control and health-promoting strategies using microbial resources.
微生物蛋白酶是由各种微生物(包括细菌和真菌)分泌的酶,由于其在食品和制药工业中的广泛应用,引起了人们的极大关注。此外,某些蛋白酶已被用于开发皮肤保健品和化妆品。本文综述了微生物蛋白酶的分类、来源、性质和应用。此外,还对不同的药理学和分子研究进行了综述。微生物蛋白酶具有多种生物学活性,如参与消化膳食蛋白质的 Arazyme、胶原酶、弹性蛋白酶和纳豆激酶,以及它们的潜在抗炎、抗癌、抗血栓和免疫调节作用。此外,还讨论了它们控制感染和治疗各种疾病的能力。最后,本文综述了微生物蛋白酶在生物技术和生物医学中的潜在应用和未来前景,并提出了进一步的研究,以利用微生物资源为疾病控制和促进健康的策略开发新的视角。