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蛋白酶的系统再思考。

A systematic reconsideration on proteases.

机构信息

Department of Biotechnology, Kumaraguru College of Technology, Coimbatore, India.

Department of Biotechnology, Kumaraguru College of Technology, Coimbatore, India.

出版信息

Int J Biol Macromol. 2019 May 1;128:254-267. doi: 10.1016/j.ijbiomac.2019.01.081. Epub 2019 Jan 18.

Abstract

Proteases are a group of large complex enzyme molecules that perform highly focused proteolysis functions. A vast quantity of the protease enzymes is predominantly sourced from microbial fermentation process, although proteases tend to natively present in plant, animals and humans. Proteases possess a pervasive importance in medical and pharmaceutical sector, because of its enriched specificity towards biomolecules. They are also actively encompassed in regulating certain physiological pathways. A distinct territory of human disorders is treated by substrate specific proteases. Enormous numbers of catalytic activities in habitual metabolism process of a living organism are protease dependent. Pilot scale researches and product development in industrial biotechnology sectors are wholly based on any one of the protease enzymes. The applications of the protease enzymes and its economic benefits of being an eco-friendly material are far-reaching. This review presents a brief overview on the classification and sources of various types of proteases. We describe the essential evidences of role of protease in different sectors. The proteases could be a potential relieves to harmful synthetic chemicals in distinctive industrial processes and thus gains global perception.

摘要

蛋白酶是一组大型复杂的酶分子,具有高度集中的蛋白水解功能。大量的蛋白酶主要来源于微生物发酵过程,尽管蛋白酶通常存在于植物、动物和人体中。由于其对生物分子的丰富特异性,蛋白酶在医学和制药领域具有普遍的重要性。它们还积极参与调节某些生理途径。特定的人类疾病领域是通过底物特异性蛋白酶来治疗的。在生物体的常规新陈代谢过程中,有大量的催化活性依赖于蛋白酶。工业生物技术领域的中试研究和产品开发完全基于一种蛋白酶酶。蛋白酶的应用及其作为环保材料的经济效益是深远的。本综述简要介绍了各种类型蛋白酶的分类和来源。我们描述了蛋白酶在不同领域的作用的重要证据。蛋白酶在不同的工业过程中可能是有害的合成化学品的潜在替代品,因此在全球范围内得到了认可。

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