Liu Jie, Han Xiaoxia, Zhou Jia, Leng Yufang
The First School of Clinical Medicine, Lanzhou University, Lanzhou, People's Republic of China.
Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou, People's Republic of China.
J Inflamm Res. 2023 Nov 2;16:4941-4951. doi: 10.2147/JIR.S427505. eCollection 2023.
Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may be an important target for treating AKI caused by various reasons, such as ischemia-reperfusion injury, rhabdomyolysis syndrome, sepsis, and nephrotoxic drugs. This paper provides a review on the regulatory mechanisms of ferroptosis and its role in AKI, which may help to provide new research ideas for the treatment of AKI and future research.
铁死亡是一种调节细胞死亡的新方式，其发生过程与细胞内铁代谢、脂质代谢、氨基酸代谢及多种信号通路密切相关。最新研究表明，铁死亡在急性肾损伤（AKI）的发病机制中起关键作用。铁死亡可能是治疗由各种原因引起的AKI的重要靶点，如缺血再灌注损伤、横纹肌溶解综合征、脓毒症和肾毒性药物。本文对铁死亡的调控机制及其在AKI中的作用进行综述，这可能有助于为AKI的治疗及未来研究提供新的研究思路。
