Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China; Ningxia low-grade resource high value utilization and environmental chemical integration technology innovation team project, Yinchuan 750021, PR China.
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China.
Fitoterapia. 2024 Jan;172:105738. doi: 10.1016/j.fitote.2023.105738. Epub 2023 Nov 7.
Phytochemical investigation on the aerial parts of Corydalis impatiens (pall.) Fisch (Papaveraceae) resulted in the identification of four previous undescribed benzylisoquinoline alkaloids, impatienines A-D (1-4), together with 14 known analogues (5-18). The structures of these compounds were elucidated by extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) as well as ECD calculations. All the compounds obtained were investigated for their inhibitory effect on the growth of A549, H1299 and HepG2 cancer cells. Compounds 7 and 15 exhibited pronounced inhibition against the A549 cancer cells with IC values of 6.81 μM and 3.17 μM, while the positive control cisplatin was 1.83 μM. Compounds 1-3 showed moderate inhibitory on the H1299 cancer cells. Compounds 4, 10-12, and 16 showed signiffcant activity against HepG2 cancer cells with IC values range of 4.41-8.75 μM.
从延胡索（罂粟科）的地上部分的植物化学研究中，鉴定出了四个以前未描述的苯并异喹啉生物碱，分别为 impatienines A-D（1-4），以及 14 个已知类似物（5-18）。通过广泛的光谱分析（IR、HR-ESIMS、1D 和 2D-NMR）以及 ECD 计算，确定了这些化合物的结构。对所有获得的化合物进行了抑制 A549、H1299 和 HepG2 癌细胞生长的活性测试。化合物 7 和 15 对 A549 癌细胞表现出显著的抑制作用，IC 值分别为 6.81 μM 和 3.17 μM，而阳性对照顺铂的 IC 值为 1.83 μM。化合物 1-3 对 H1299 癌细胞表现出中等抑制作用。化合物 4、10-12 和 16 对 HepG2 癌细胞表现出显著的活性，IC 值范围为 4.41-8.75 μM。
