Zin'kovskiĭ V G, Bogatskiĭ A V, Golovenko N Ia, Seredenin S B, Andronati S A
Biull Eksp Biol Med. 1979 Jun;87(6):561-3.
During 5 days after intraperitoneal injection of 14C-phenazepam into albino rats, about 77% of the total radioactivity was excreted with urine and feces in both intact animals and in those premedicated with phenazepam for 15 days. The excretory processes are described by the first order equations. The rates of phenazepam total excretion are identical in single and repeated injections. At the same time, phenazepam injected into the animals at a single dose is predominantly excreted with urine, while in multiple administration it is excreted with feces. Excretion of phenazepam with urine acquires the biexponential features, provided it is injected in multiple doses.
给白化大鼠腹腔注射14C-非那西泮后的5天内，完整动物以及预先用非那西泮预处理15天的动物中，约77%的总放射性通过尿液和粪便排出。排泄过程可用一级方程描述。单次注射和重复注射时非那西泮的总排泄率相同。同时，单次给动物注射非那西泮时主要通过尿液排出，而多次给药时则通过粪便排出。如果多次给药，非那西泮通过尿液排出呈现双指数特征。
