[14C-非那西泮及其代谢产物在对白鼠单次和长期给药后的肝脏、大脑和血浆中的分布]
[Distribution of 14C-phenazepam and its metabolites in the liver, brain and blood plasma in single and prolonged administration to white rats].
作者信息
Golovenko N Ia, Zin'kovskiĭ V G, Seredenin S B, Andronati S A, Iakubovskaia L N
出版信息
Farmakol Toksikol. 1980 Mar-Apr;43(2):144-8.
PMID:6108232
Abstract
The distribution pattern of 14C-phenazepam and some of its metabolites in the liver, brain and blood plasma at a prolonged (45 days) administration to rats does not differ from that after a single administration. The liver and brain demonstrated an increase in the content of 3-hydroxyderivative. Glycuronide was found only in the liver.
摘要
对大鼠长期（45天）给予14C-非那西泮及其某些代谢物后，其在肝脏、脑和血浆中的分布模式与单次给药后并无差异。肝脏和脑中3-羟基衍生物的含量有所增加。仅在肝脏中发现了葡糖醛酸苷。
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