Wong B S, Norman D C
J Am Geriatr Soc. 1987 Jan;35(1):21-6. doi: 10.1111/j.1532-5415.1987.tb01314.x.
A prospective, controlled, crossover study on drug compliance was initiated in 22 elderly patients from a geriatric clinic. Half of the patients received their pills from a commercially prepared calendar mealtime blister-pak; the remaining patients received their medication from standard pill bottles. At the end of three months the two groups were crossed over. Pill count and issuance of a new drug supply were done monthly to assess compliance. It was found that the average noncompliance index was significantly decreased (9.17 to 2.04) with the blister-pak packaging system. The relationship of age, Folstein mini-mental status, overcompliance, frequency of dosing interval, and living situation were also explored.