Aratikatla Adarsh, Ghandour Samir, Maffulli Nicola, Gupta Manu, Gupta Ashim
The Royal College of Surgeons in Ireland, Dublin, Ireland.
Faculty of Medicine, The University of Balamand, Beirut, Lebanon.
Front Pain Res (Lausanne). 2023 Oct 24;4:1281277. doi: 10.3389/fpain.2023.1281277. eCollection 2023.
The temporomandibular joint (TMJ) is crucial for functions of daily living such as mastication and articulation. Common TMJ issues include osteoarthritis, internal derangement, and myofascial pain dysfunction. Conservative methods such as physical therapy and medications are used, with surgical options such as arthroscopy and replacement for severe cases. Emerging regenerative medicine explores non-surgical treatments using human stem cells from umbilical cord derivatives, showing potential for tissue regeneration in TMJ disorders. A systematic search was conducted across PubMed, Embase, Scopus, and Web of Science databases, adhering to PRISMA guidelines, aiming to identify relevant articles published in English until August 2023. The search used specific terms to target , preclinical, and clinical studies on umbilical cord (UC)-derived tissue and mesenchymal stem cells (MSCs) for treating TMJ disorders. The search was extended to three clinical trial registries for on-going investigations related to UC tissue and MSCs for TMJ disorder management. The studies included in this article report the safety and efficacy profiles of allogenically acquired, umbilical cord-derived tissues and associated mesenchymal stem cells for temporomandibular joint ailments, future adequately powered, randomized controlled trials are warranted to conclusively justify the clinical use of this biologic therapy.
颞下颌关节（TMJ）对于咀嚼和发音等日常生活功能至关重要。常见的颞下颌关节问题包括骨关节炎、关节内紊乱和肌筋膜疼痛功能障碍。采用物理治疗和药物等保守方法，对于严重病例则采用关节镜检查和置换等手术选择。新兴的再生医学探索使用来自脐带衍生物的人类干细胞进行非手术治疗，显示出在颞下颌关节疾病中组织再生的潜力。按照PRISMA指南，在PubMed、Embase、Scopus和科学网数据库中进行了系统检索，旨在识别截至2023年8月以英文发表的相关文章。该检索使用特定术语来查找关于脐带（UC）衍生组织和间充质干细胞（MSCs）治疗颞下颌关节疾病的临床前和临床研究。检索范围扩展到三个临床试验注册库，以查找与UC组织和MSCs治疗颞下颌关节疾病相关的正在进行的研究。本文纳入的研究报告了异体获取的脐带衍生组织和相关间充质干细胞治疗颞下颌关节疾病的安全性和有效性概况，未来需要进行充分有力的随机对照试验，以最终证明这种生物疗法的临床应用合理性。
