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Role of intravenous ketamine in the pathogenesis of secondary sclerosing cholangitis in critically ill patients: perpetrator or innocent bystander? Answers provided by forensic toxicology.

作者信息

Leonhardt Silke, Baumann Sven, Jürgensen Christian, Hüter Lars, Leonhardt Julia

机构信息

Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Department of Forensic Toxicology, Institute of Legal Medicine, University of Leipzig, Johannisallee 28, 04103, Leipzig, Germany.

出版信息

Intensive Care Med. 2023 Dec;49(12):1549-1551. doi: 10.1007/s00134-023-07257-8. Epub 2023 Nov 9.

DOI:10.1007/s00134-023-07257-8
PMID:37943301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10709220/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ac/10709220/2295d47f5d62/134_2023_7257_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ac/10709220/2295d47f5d62/134_2023_7257_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ac/10709220/2295d47f5d62/134_2023_7257_Fig1_HTML.jpg

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2
Ketamine Stability over Six Months of Exposure to Moderate and High Temperature Environments.氯胺酮在中温和高温环境下暴露六个月的稳定性。
Prehosp Emerg Care. 2022 May-Jun;26(3):422-427. doi: 10.1080/10903127.2021.1934203. Epub 2021 Jun 21.
3
Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.氯胺酮和去甲氯胺酮在常温及4°C条件下于全血中的稳定性。
Diagnostics (Basel). 2024 Aug 19;14(16):1804. doi: 10.3390/diagnostics14161804.
Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4104. Epub 2017 Nov 9.
4
Influence of Different Sewer Biofilms on Transformation Rates of Drugs.不同污水生物膜对药物转化率的影响。
Environ Sci Technol. 2016 Dec 20;50(24):13351-13360. doi: 10.1021/acs.est.6b04200. Epub 2016 Dec 8.
5
Beyond-use dating of extemporaneously compounded ketamine, acepromazine, and xylazine: safety, stability, and efficacy over time.氯胺酮、乙酰丙嗪和赛拉嗪临时配制药剂的有效期：随时间推移的安全性、稳定性和有效性。
J Am Assoc Lab Anim Sci. 2009 Nov;48(6):718-26.
6
THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION?环境与疾病：关联还是因果关系？
Proc R Soc Med. 1965 May;58(5):295-300. doi: 10.1177/003591576505800503.
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Effect of biliary excretion on ketamine anaesthesia in the rat.
Br J Anaesth. 1980 Jan;52(1):23-8. doi: 10.1093/bja/52.1.23.