小儿髓母细胞瘤的最新进展。
Recent Advances in Pediatric Medulloblastoma.
机构信息
Brain Tumor Institute, Children's National Hospital, Washington D C, USA.
Division of Hematology and Oncology, Children's National Hospital, Washington D C, USA.
出版信息
Curr Neurol Neurosci Rep. 2023 Dec;23(12):841-848. doi: 10.1007/s11910-023-01316-9. Epub 2023 Nov 9.
Abstract
PURPOSE OF REVIEW
Review recent advances in the understanding of pediatric medulloblastoma including etiology, biology, radiology, and management of pediatric medulloblastoma.
RECENT FINDINGS
The classic four subgroups have been reclassified and further subdivided based on new molecular findings. Research is revealing the cell origins of the different subtypes of medulloblastoma. There has been continued personalization of management based on molecular parameters. While many advances have been made in the knowledge base of this most common malignant pediatric brain tumor, there has not yet been translation into more effective therapies to prolong survival in all subgroups with the possible exception of children with group 3 disease. Quality of life remains a major challenge for long-term survivors.
摘要
目的综述
小儿髓母细胞瘤理解的最新进展，包括病因、生物学、影像学和小儿髓母细胞瘤的治疗。
最近的发现
经典的四个亚组根据新的分子发现进行了重新分类和进一步细分。研究揭示了不同亚型髓母细胞瘤的细胞起源。基于分子参数，管理的个体化一直在继续。虽然在这种最常见的小儿脑恶性肿瘤的知识库中已经取得了许多进展，但尚未转化为更有效的治疗方法，以延长所有亚组的生存时间，除了可能组 3 疾病的儿童。对于长期幸存者来说，生活质量仍然是一个主要挑战。
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