Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Geroscience. 2024 Apr;46(2):2755-2764. doi: 10.1007/s11357-023-00971-7. Epub 2023 Nov 9.
We conducted a meta-analysis of randomized controlled trials investigating the effects of aerobic exercise training (AET) lasting ≥ 4 weeks on hippocampal volume and cardiorespiratory fitness (CRF) in cognitively unimpaired, healthy older individuals. Random-effects robust variance estimation models were used to test differences between AET and controls, while meta-regressions tested associations between CRF and hippocampal volume changes. We included eight studies (N = 554) delivering fully supervised AET for 3 to 12 months (M = 7.8, SD = 4.5) with an average AET volume of 129.85 min/week (SD = 45.5) at moderate-to-vigorous intensity. There were no significant effects of AET on hippocampal volume (SMD = 0.10, 95% CI - 0.01 to 0.21, p = 0.073), but AET moderately improved CRF (SMD = 0.30, 95% CI 0.12 to 0.48, p = 0.005). Improvement in CRF was not associated with changes in hippocampal volume (b = 0.05, SE = 0.51, p = 0.923). From the limited number of studies, AET does not seem to impact hippocampal volume in cognitively unimpaired, healthy older individuals. Notable methodological limitations across investigations might mask the lack of effects.
我们进行了一项荟萃分析，纳入了八项随机对照试验，这些试验均研究了持续时间≥4 周的有氧运动训练（AET）对认知正常的健康老年人的海马体体积和心肺功能（CRF）的影响。使用随机效应稳健方差估计模型来检验 AET 与对照组之间的差异，而元回归则检验 CRF 与海马体体积变化之间的关联。这些试验共纳入 554 名参与者，均接受了为期 3 至 12 个月（M=7.8，SD=4.5）的全监督 AET，平均每周 AET 量为 129.85 分钟（SD=45.5），强度为中等至剧烈。AET 对海马体体积没有显著影响（SMD=0.10，95%CI-0.01 至 0.21，p=0.073），但 AET 适度改善了 CRF（SMD=0.30，95%CI 0.12 至 0.48，p=0.005）。CRF 的改善与海马体体积的变化无关（b=0.05，SE=0.51，p=0.923）。从有限数量的研究来看，AET 似乎不会影响认知正常的健康老年人的海马体体积。各研究之间存在明显的方法学局限性，可能掩盖了缺乏效果的事实。
