化学药物递送系统：I. 氨苯砜前药的制备与评价
Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone.
作者信息
Kulkarni V M, Mishra D S
出版信息
Indian J Lepr. 1985 Oct-Dec;57(4):756-62.
PMID:3835207
Abstract
Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.
摘要
已制备了几种氨苯砜的前体药物，并在体内对母体药物的释放进行了评估。前体药物：4,4'-二丁酰氨基二苯砜在臀肌内注射的兔子中，血药浓度高于0.5微克/毫升的氨苯砜约持续34天。已将结果与氨苯砜和双乙酰氨苯砜进行了比较。
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