Kulkarni V M, Mishra D S
Indian J Lepr. 1985 Oct-Dec;57(4):756-62.
Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.
已制备了几种氨苯砜的前体药物，并在体内对母体药物的释放进行了评估。前体药物：4,4'-二丁酰氨基二苯砜在臀肌内注射的兔子中，血药浓度高于0.5微克/毫升的氨苯砜约持续34天。已将结果与氨苯砜和双乙酰氨苯砜进行了比较。
