Ghosal Souvik, Bag Sagar, Burman Mangal Deep, Bhowmik Sudipta
Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Pondy-Cuddalore Main Road, Pillaiyarkuppam, Pondicherry 607402, India.
Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
J Phys Chem Lett. 2023 Nov 23;14(46):10328-10332. doi: 10.1021/acs.jpclett.3c02632. Epub 2023 Nov 9.
In this investigation, different multispectroscopic analytical techniques have been used to explore the interaction between polyethylene microplastics (PE-MPs) and human hemoglobin (HHb), an oxygen carrier in the human blood circulatory system. Ultraviolet-visible absorption studies have demonstrated that HHb molecules may interact with PE-MPs, and thermal melting studies have indicated that PE-MPs have a stabilizing effect on HHb. Further circular dichroism and Fourier transform infrared spectroscopic studies have revealed the distinct changes in HHb's secondary structures caused by the formation of the HHb-PE-MP binding complex. These findings imply that PE-MPs could enter the blood circulation system of humans and may be hazardous to humans. This work explains the potential binding interaction of microplastics at the molecular level and offers insight into the intermolecular interaction between PE-MPs and HHb.
在本研究中，采用了不同的多光谱分析技术来探究聚乙烯微塑料（PE-MPs）与人体血红蛋白（HHb，人体血液循环系统中的一种氧载体）之间的相互作用。紫外可见吸收研究表明，HHb分子可能与PE-MPs相互作用，热熔融研究表明，PE-MPs对HHb具有稳定作用。进一步的圆二色光谱和傅里叶变换红外光谱研究揭示了由HHb-PE-MP结合复合物的形成导致的HHb二级结构的明显变化。这些发现意味着PE-MPs可能进入人体血液循环系统并可能对人体有害。这项工作解释了微塑料在分子水平上的潜在结合相互作用，并深入了解了PE-MPs与HHb之间的分子间相互作用。
