Burman Mangal Deep, Bag Sagar, Ghosal Souvik, Bhowmik Sudipta
Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Pondy-Cuddalore Main Road, Pillaiyarkuppam, Pondicherry 607402, India.
ACS Pharmacol Transl Sci. 2025 Feb 25;8(3):636-653. doi: 10.1021/acsptsci.4c00684. eCollection 2025 Mar 14.
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which lead to the glycation of proteins and the formation of advanced glycation end products (AGEs). These AGEs contribute to oxidative stress, inflammation, and the development of complications such as cardiovascular disease, nephropathy, and anemia, significantly increasing mortality rates among diabetic patients. This Review focuses on the role of glycation inhibitors as a potential strategy to prevent AGE-related pathologies. While synthetic glycation inhibitors have shown promise, their adverse effects highlight the need for safer alternatives. We specifically explore a range of natural compounds-flavonoids, curcuminoids, terpenes, stilbenes, lignans, and coumarins-that have demonstrated significant antiglycating properties. The mechanisms through which these natural products inhibit glycation, including antioxidant activity, metal ion chelation, and direct interference with the glycation process, are discussed in detail. This review underscores the potential of natural products as effective and safer glycation inhibitors, offering a promising avenue for the development of therapeutic strategies against diabetes and AGE-related disorders.
糖尿病是一种慢性代谢紊乱疾病，其特征为血糖水平升高，这会导致蛋白质糖基化并形成晚期糖基化终末产物（AGEs）。这些AGEs会引发氧化应激、炎症反应，并导致心血管疾病、肾病和贫血等并发症的发生，显著提高糖尿病患者的死亡率。本综述聚焦于糖基化抑制剂作为预防AGE相关病理状况的潜在策略所发挥的作用。虽然合成糖基化抑制剂已显示出前景，但其副作用凸显了对更安全替代物的需求。我们特别探讨了一系列天然化合物——类黄酮、姜黄素类、萜类、芪类、木脂素类和香豆素类——它们已展现出显著的抗糖基化特性。详细讨论了这些天然产物抑制糖基化的机制，包括抗氧化活性、金属离子螯合以及对糖基化过程的直接干扰。本综述强调了天然产物作为有效且更安全的糖基化抑制剂的潜力，为开发针对糖尿病和AGE相关疾病的治疗策略提供了一条有前景的途径。
