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体内长期暴露于溴化物的大脑皮质中γ-氨基丁酸能系统的神经化学

Neurochemistry of GABAergic system in cerebral cortex chronically exposed to bromide in vivo.

作者信息

Balcar V J, Erdö S L, Joó F, Kása P, Wolff J R

出版信息

J Neurochem. 1987 Jan;48(1):167-9. doi: 10.1111/j.1471-4159.1987.tb13142.x.

DOI:10.1111/j.1471-4159.1987.tb13142.x
PMID:3794698
Abstract

Neurochemical correlates of GABAergic synaptic transmission [binding, uptake, metabolism, and tissue content of gamma-aminobutyric acid (GABA)] were investigated in the cortex of rats that had been given 27 mM bromide in drinking water for periods of time ranging from 1 day to 1 month. No effect of bromide on any of the parameters was found and it is concluded that chronic administration of bromide has no profound effect on GABAergic inhibitory system in the rat cortex.

摘要

在饮用含27 mM溴化物的水1天至1个月不等的大鼠皮层中,研究了γ-氨基丁酸(GABA)能突触传递的神经化学相关性[GABA的结合、摄取、代谢和组织含量]。未发现溴化物对任何参数有影响,得出的结论是,长期给予溴化物对大鼠皮层的GABA能抑制系统没有深远影响。

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