Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
J Infect Dis. 2024 Mar 14;229(3):780-785. doi: 10.1093/infdis/jiad488.
The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women's Interagency HIV Study (2004-2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.
绝经期是心血管风险的关键时期，但 HIV 相关知识有限。我们研究了妇女艾滋病研究机构间合作组（2004-2019 年；979 名女性/3247 人次就诊；72%患有 HIV）中颈动脉内膜中层厚度（CIMT）的纵向变化。在仅患有 HIV 的女性中，与仍处于绝经前的女性相比，处于绝经过渡阶段的女性 CIMT 随年龄增长的进展更大（斜率差异=1.64μm/年，P=0.002）；并且在绝经过渡前（3.47μm/年，P=0.002）和绝经过渡期间（9.41μm/年，P<.0001）CIMT 随时间增加，而绝经过渡后（2.9μm/年，P=0.19）则没有增加。在患有 HIV 的女性中，绝经可能会加速 CIMT 测量的亚临床动脉粥样硬化。
