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The search for more clinically meaningful research designs: single-patient randomized clinical trials.

作者信息

Porta M S

出版信息

J Gen Intern Med. 1986 Nov-Dec;1(6):418-9. doi: 10.1007/BF02596430.

DOI:10.1007/BF02596430
PMID:3794841
Abstract
摘要

相似文献

1
The search for more clinically meaningful research designs: single-patient randomized clinical trials.
J Gen Intern Med. 1986 Nov-Dec;1(6):418-9. doi: 10.1007/BF02596430.
2
Allocation of patients to treatment in clinical trials.临床试验中患者的治疗分配。
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Selection bias and randomized consent designs.选择偏倚与随机同意设计
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Strategy and alternate randomized designs in cancer clinical trials.癌症临床试验中的策略与交替随机设计
Cancer Treat Rep. 1982 May;66(5):1095-100.
5
Obtaining medically meaningful answers from an overview of randomized clinical trials.
Stat Med. 1987 Apr-May;6(3):281-94. doi: 10.1002/sim.4780060314.
6
Bayesian adaptive biased-coin designs for clinical trials with normal responses.用于具有正态响应的临床试验的贝叶斯自适应偏币设计
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Randomization designs in comparative clinical trials.比较性临床试验中的随机化设计。
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8
Designing medical and educational intervention studies. A review of some alternatives to conventional randomized controlled trials.设计医学与教育干预研究。对传统随机对照试验的一些替代方法的综述。
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9
Factorial designs for randomized clinical trials.随机临床试验的析因设计
Cancer Treat Rep. 1985 Oct;69(10):1055-63.
10
The competing objectives of randomized trials.
N Engl J Med. 1980 Oct 30;303(18):1059-60. doi: 10.1056/NEJM198010303031812.

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Aspartame and seizures.阿斯巴甜与癫痫发作。
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Overcoming implementation challenges of personalized cancer therapy.克服个性化癌症治疗实施挑战。
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Family medicine resident research: how about an N of 1 trial?家庭医学住院医师研究：单病例试验怎么样？

本文引用的文献

1
THE TWO-PERIOD CHANGE-OVER DESIGN AN ITS USE IN CLINICAL TRIALS.两阶段交叉设计及其在临床试验中的应用。
Biometrics. 1965 Jun;21:467-80.
2
The crossover experiment for clinical trials.
Biometrics. 1980 Mar;36(1):69-79.
3
Crossover and self-controlled designs in clinical research.临床研究中的交叉设计和自身对照设计。
N Engl J Med. 1984 Jan 5;310(1):24-31. doi: 10.1056/NEJM198401053100106.
Can Fam Physician. 1989 Apr;35:849-52.
4
N of 1 trials. Research is needed into why such trials are not more widely used.单病例试验。需要研究为何此类试验未得到更广泛应用。
BMJ. 1996 Aug 17;313(7054):427. doi: 10.1136/bmj.313.7054.427b.
5
Randomised study of n of 1 trials versus standard practice.n-of-1试验与标准治疗方法的随机对照研究。
BMJ. 1996 Apr 27;312(7038):1069-74. doi: 10.1136/bmj.312.7038.1069.
6
N-of-1 clinical trials. A technique for improving medical therapeutics.单病例临床试验。一种改善医学治疗效果的技术。
West J Med. 1990 Jan;152(1):52-6.
4
The use of non-parametric methods in the statistical analysis of the two-period change-over design.两阶段交叉设计统计分析中非参数方法的应用
Biometrics. 1972 Jun;28(2):577-84.
5
Statistical concepts fundamental to investigations.调查的基本统计概念。
N Engl J Med. 1985 Oct 17;313(16):1026. doi: 10.1056/NEJM198510173131617.
6
Warning against poor application of statistical tests: confusing experimental intervention and time trends.谨防统计检验应用不当：混淆实验干预与时间趋势。
Eur J Clin Pharmacol. 1986;30(2):131-2. doi: 10.1007/BF00614289.
7
Determining optimal therapy--randomized trials in individual patients.
N Engl J Med. 1986 Apr 3;314(14):889-92. doi: 10.1056/NEJM198604033141406.
8
Single-patient trials.单病例试验。
Lancet. 1986 Jul 5;2(8497):42. doi: 10.1016/s0140-6736(86)92585-7.
9
Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir.单病例随机临床试验。用于确定科克可控回肠造口贮袋炎患者的最佳治疗方法。
Lancet. 1986 Mar 29;1(8483):726-8. doi: 10.1016/s0140-6736(86)91112-8.
10
The analysis of the two-period repeated measurements crossover design with application to clinical trials.两阶段重复测量交叉设计的分析及其在临床试验中的应用。
Biometrics. 1977 Mar;33(1):261-9.